Issac Guerendo best prop bets against the Lions

The San Francisco 49ers will face the Detroit Lions in an NFC Championship rematch from last year. This time, though, the situation is different. The Detroit Lions are trying to secure the No. 1 seed, while the 49ers have only won six games this season. They will face off on Monday Night Football at 8:15 p.m. ET.

Below, I detail some prop bets for Issac Guerendo against the Lions tonight.

Best Issac Guerendo Prop Bets on DraftKings Sportsbook

Issac Guerendo over 63.5 Rushing Yards (-115)

Guerendo has made the most of the opportunities he has been given this season. He has had 10 or more rushing attempts in four games this year. He has totaled more than 63.5 rushing yards in three of them. Guerendo is -115 to record at least 64 yards against the Lions tonight on DraftKings Sportsbook.

If the 49ers can keep this game close throughout the first half, they can use their rushing game, led by Guerendo. This season, Guerendo is averaging 5.2 yards per rush, and RBs are averaging 68 rushing yards per game against Detroit.

Issac Guerendo Anytime Touchdown Scorer (-115)

Guerendo has three touchdowns in the last three weeks. He scored four touchdowns in his previous four games, with four or more carries. He is -115 to score a touchdown against the Lions.

He has been an efficient playmaker for the 49ers offense when he has been on the field. With Christian McCaffrey and Jordan Mason on the IR for the rest of the season, Guerendo will get most of the work in the backfield. When the 49ers get in the red zone, they love to utilize their RBs. Opposing RBs have scored 12 total touchdowns against the Lions’ defense this season.

All odds provided by DraftKings Sportsbook, lines and odds subject to change.

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