Systems Biology: An Introduction to Metabolic Control Analysis

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Publisher ‏ : ‎ Ambrosius Publishing (February 26, 2018)
Language ‏ : ‎ English
Paperback ‏ : ‎ 284 pages
ISBN-10 ‏ : ‎ 0982477368
ISBN-13 ‏ : ‎ 978-0982477366
Item Weight ‏ : ‎ 2.31 pounds
Dimensions ‏ : ‎ 7 x 0.67 x 10 inches

Systems Biology: An Introduction to Metabolic Control Analysis

Systems biology is a rapidly growing field that seeks to understand biological systems as a whole, rather than focusing on individual components. One important aspect of systems biology is metabolic control analysis, which aims to quantify the control that different enzymes and pathways have over the overall metabolic network.

Metabolic control analysis provides a quantitative framework for understanding how changes in enzyme activity or metabolite concentrations affect the flux of metabolites through a pathway. By analyzing the control coefficients of different components within a metabolic network, researchers can identify key regulatory points and potential drug targets.

One of the key concepts in metabolic control analysis is the notion of flux control coefficients, which measure the sensitivity of a metabolic pathway to changes in enzyme activity. By calculating these coefficients, researchers can determine which enzymes have the greatest influence on the overall flux through a pathway.

Overall, metabolic control analysis provides a powerful tool for understanding the complex interactions within metabolic networks. By quantifying the control that different components have over the system, researchers can gain insights into the underlying regulatory mechanisms and potential therapeutic interventions.

In conclusion, metabolic control analysis is a valuable tool within the broader field of systems biology. By providing a quantitative framework for understanding metabolic regulation, this approach can help researchers unravel the complexities of biological systems and develop new strategies for treating diseases.
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