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Tag: CKD
FDA Expands Semaglutide Use for CV, Kidney Risks in T2D, CKD
Today the FDA announced that it had expanded semaglutide’s (Ozempic; Novo Nordisk) indications to include patients with type 2 diabetes (T2D) and chronic kidney disease (CKD). The move means the drug is the sole glucagon-like peptide-1 receptor agonist (GLP-1 RA) approved for mitigating cardiovascular (CV) risks and kidney disease that has advanced—when added to standard care—in this patient population. This decision was informed by the FLOW (NCT03819153) phase 3b kidney outcomes trial, which found a correlation between once-weekly injections of semaglutide and a subsequently reduced risk of both cardiovascular disease (CVD) and adverse kidney outcomes.1
For the FLOW trial, those in the treatment group exhibited a statistically significant 24% risk decrease for multiple adverse kidney outcomes, including progressive and end-stage kidney disease, as well as a nearly 5% risk decrease for CVD-related death at 3 years compared with the placebo group. | image credit: cartoon – stock.adobe.com
“This approval for Ozempic allows us to more broadly address conditions within cardiovascular-kidney-metabolic syndrome, which affects millions of adults and could have serious consequences if left untreated,” Anna Windle, PhD, senior vice president, Clincal Development, Medicat & Regulatory Affairs, Novo Nordisk, said in a statement.
Semaglutide received its first FDA approval back in 2017; at the time, it was only indicated for T2D to improve patients’ glucose and was recommended alongside exercise and dietary modifications. By 2020, semaglutide’s indication was expanded to include patients with T2D and forms of heart disease to mitigate their risks for stroke, heart attack, other CV episodes, or death.
CKD poses an additional risk for patients with T2D, occurring in around 40% of this population, and can influence the likelihood of developing CV issues and individual mortality risks. Diabetes itself remains a primary driver of CKD. As the aging population is expected to grow, data project a rising incidence of diabetes that could, in turn, result in a greater rates of kidney failure and CKD.2
“A large portion of patients I treat experience serious kidney complications and comorbidities, with some even requiring dialysis. Today’s decision by the FDA offers hope for the millions of adults living with both conditions and provides an additional treatment option, representing a significant advancement for my patients,” Richard E. Pratley, MD, medical director, AdventHealth Diabetes Institute located in Orlando, Florida, noted in a statement.1
The FLOW phase 3b kidney outcomes trial compared the efficacy of semaglutide 1 mg with a placebo, with one of the primary outcomes of interest being achieving and sustaining at least a 50% reduction in estimated glomerular filtration rate (eGFR), as well as an eGFR less than 15 mL/min/1.73 m2. Outcomes related to CV or renal death, as well as chronic renal replacement therapy, were additional primary end points. The study population comprised 1767 adults with T2D and CKD in the semaglutide group and 1766 adults with T2D and CKD in the placebo group. Patients were featured from 28 countries, with the trial being conducted across an estimated 400 sites.
Those in the treatment group exhibited a statistically significant (P < .05) 24% risk decrease for multiple adverse kidney outcomes, including progressive and end-stage kidney disease, as well as a nearly 5% risk decrease for CVD-related death at 3 years compared with the placebo group.
“With this new indication, Ozempic stands out uniquely as the most broadly indicated GLP-1 RA in its class. We are proud to continue advancing innovations that will have a meaningful impact for this patient population, underscoring Novo Nordisk’s commitment to cardiometabolic care,” Wilde commented.
References
1. FDA approves Ozempic (semaglutide) as the only GLP-1 RA to reduce the risk of worsening kidney disease and cardiovascular death in adults with type 2 diabetes and chronic kidney disease. PR Newswire. January 28, 2025. Accessed January 28, 2025. https://www.prnewswire.com/news-releases/fda-approves-ozempic-semaglutide-as-the-only-glp-1-ra-to-reduce-the-risk-of-worsening-kidney-disease-and-cardiovascular-death-in-adults-with-type-2-diabetes-and-chronic-kidney-disease-302362466.html
2. Diabetes and chronic kidney disease. National Kidney Foundation. Updated January 2016. Accessed January 28, 2025. https://www.kidney.org/diabetes-and-chronic-kidney-disease
The FDA has recently expanded the use of semaglutide, a medication commonly used to treat type 2 diabetes, to also include reducing the risk of cardiovascular events and kidney disease in patients with type 2 diabetes and chronic kidney disease.This decision comes after the results of a large clinical trial showed that semaglutide significantly reduced the risk of major cardiovascular events such as heart attack and stroke, as well as the progression of kidney disease in patients with type 2 diabetes and chronic kidney disease.
Semaglutide works by increasing insulin production in the body and decreasing the production of glucose in the liver, helping to lower blood sugar levels in patients with type 2 diabetes. In addition to its benefits for controlling blood sugar levels, semaglutide has now been shown to also reduce the risk of serious complications such as heart disease and kidney disease in these patients.
This expanded use of semaglutide provides a new treatment option for patients with type 2 diabetes and chronic kidney disease who are at risk for these serious complications. Patients should consult with their healthcare provider to determine if semaglutide is the right treatment option for them.
Tags:
- FDA approval
- Semaglutide
- Cardiovascular risks
- Kidney risks
- Type 2 diabetes
- Chronic kidney disease
- FDA expansion
- Semaglutide use
- Diabetes treatment
- CKD management.
#FDA #Expands #Semaglutide #Kidney #Risks #T2D #CKD
CKD Retino Collagen Intensive Cream – Retinal Spot Collagen Cream for Fine Lines, Deep Wrinkles, and Sagging Reduction. Anti-Aging and Youthful Skin. Korean Skin Care. 0.84 fl oz
Price: $25.00
(as of Jan 25,2025 22:25:02 UTC – Details)
1. If any abnormal symptoms or side effects such as red spots, swelling, or itching occur at the application site during or after use, especially when exposed to direct sunlight, consult a specialist. 2. Avoid using the product on wounded areas. 3. Keep out of reach of children. 4. Store away from direct sunlight.
Product Dimensions : 3 x 2 x 3 inches; 1.45 ounces
Manufacturer : CKD Healthcare Group
ASIN : B0DKF76GKK
Country of Origin : Korea, Republic ofANTI-AGING NECK CREAM FOR WRINKLES & FIRMNESS: CKD Intensive Neck Cream targets deep wrinkles and fine lines on the neck using small molecular 300 Dalton collagen and retinal. This formula enhances elasticity, promoting firmer, smoother skin while reducing signs of aging.
BOOSTS COLLAGEN & FIRMS SKIN: Enriched with hydrolyzed collagen and retinal, this neck cream improves skin elasticity by penetrating deep layers. It boosts collagen production, reduces deep wrinkles, and helps firm the jawline for a more youthful, lifted appearance.
LIGHTWEIGHT, FAST-ABSORBING FORMULA: This non-greasy, unscented cream absorbs quickly, delivering immediate and long-lasting anti-aging benefits without leaving a sticky residue. Ideal for everyday use, it strengthens the skin barrier and prevents moisture loss.
MULTI-USE ANTI-WRINKLE TREATMENT: Though designed for the neck, CKD Intensive Neck Cream can be used on other areas prone to wrinkles, such as the nasolabial folds and crow’s feet. It’s perfect for those seeking a versatile anti-aging solution for the face and neck.
KOREAN ROOTS WITH PHARMACEUTICAL EXPERTISE: Developed by Chung Kun Dang, a trusted name in the pharmaceutical industry in South Korea, CKD beauty products leverage advanced scientific research and high-quality ingredients to ensure optimal efficacy and safety for your skin. Experience the difference of skincare grounded in medical innovation.
Are you looking for a powerful anti-aging cream that targets fine lines, deep wrinkles, and sagging skin? Look no further than CKD Retino Collagen Intensive Cream!This Korean skincare product is specifically formulated to combat the signs of aging and promote youthful, radiant skin. The key ingredient in this cream is retinol, a form of vitamin A that helps to increase cell turnover and stimulate collagen production. Collagen is essential for maintaining skin elasticity and firmness, helping to reduce the appearance of wrinkles and sagging.
With regular use of the CKD Retino Collagen Intensive Cream, you can expect to see a noticeable improvement in the texture and tone of your skin. Fine lines will be smoothed out, deep wrinkles will be minimized, and sagging skin will be lifted and tightened.
This cream comes in a convenient 0.84 fl oz size, making it perfect for travel or on-the-go use. Experience the transformative power of retinol and collagen with CKD Retino Collagen Intensive Cream and achieve a more youthful complexion today!
#CKD #Retino #Collagen #Intensive #Cream #Retinal #Spot #Collagen #Cream #Fine #Lines #Deep #Wrinkles #Sagging #Reduction #AntiAging #Youthful #Skin #Korean #Skin #Care,0.84 fl ozCKD Retino Collagen Small Molecule Moisturizing Cream 70g Firming K-Beauty
CKD Retino Collagen Small Molecule Moisturizing Cream 70g Firming K-Beauty
Price : 26.98
Ends on : N/A
View on eBay
Introducing the CKD Retino Collagen Small Molecule Moisturizing Cream! This luxurious K-Beauty product is formulated with collagen-boosting ingredients to help firm and hydrate the skin, leaving you with a youthful and radiant complexion.This 70g cream is packed with small molecule retinol, known for its anti-aging properties and ability to improve skin texture. It also contains collagen, which helps to plump and firm the skin, reducing the appearance of fine lines and wrinkles.
Say goodbye to dry, dull skin and hello to a more youthful and radiant complexion with the CKD Retino Collagen Small Molecule Moisturizing Cream. Give your skin the love and care it deserves with this must-have K-Beauty product! #CKD #KBeauty #Skincare #MoisturizingCream #AntiAging #FirmingCream
#CKD #Retino #Collagen #Small #Molecule #Moisturizing #Cream #70g #Firming #KBeauty,ages 3+CKD Vita C Teca Blemish Shot Mask – Hydrogel Firming Face Mask Sheet with Pure Vitamin C & Centella Asiatica, Radiance, Relief for Dark Spots & Blemishes, 10 sheets
Price: $48.00
(as of Jan 24,2025 08:07:57 UTC – Details)
For external use only.
Product Dimensions : 6.3 x 7 x 0.2 inches; 1.12 Pounds
Manufacturer : IMINE CO.,LTD.
ASIN : B0D9N3X76W
Country of Origin : Korea, Republic ofINTENSIVE HYDRATION AND FIRMING: Experience a new level of skin rejuvenation with the Vita C Teca Blemish Shot Mask. This hydrogel mask sheet delivers 99% pure vitamin C directly to your skin, enhancing firmness and hydration. Ideal for revitalizing tired and dull skin, this mask ensures lasting moisture retention even after removal.
TARGETED BLEMISH CONTROL: Effective within just two weeks, our mask helps reduce the appearance of dark spots, blemishes, and pigmentation, while also smoothing uneven skin textures. Achieve a clearer, more refined complexion with regular use, designed to bring out your skin’s natural brightness without harsh chemicals.
POWERFUL BLEND OF ACTIVE INGREDIENTS: Packed with a high-performance mix of Cica, vitamin C, arbutin, glutathione, and tranexamic acid, this mask actively fights the root causes of skin discoloration and dullness. Each ingredient is carefully chosen to support skin health and promote a balanced, even skin tone.
FORMULATED FOR DULL AND UNEVEN SKIN TONES: The Vita C Teca Blemish Shot Mask is specially designed for those struggling with dull and uneven skin tones. This mask utilizes a unique blend of ingredients to provide clarity and a smoother texture, reviving your skin’s youthful radiance.
EASY APPLICATION PROCESS: For optimal results, use the mask after cleansing and toning. Apply the two-part mask to your face, and leave it until it turns transparent, indicating full absorption of the active ingredients. Remove the mask and pat in any remaining essence to maximize benefits. Suitable for use before sleep or as a preparatory step in your skincare routine.
Introducing the CKD Vita C Teca Blemish Shot Mask – the ultimate solution for radiant, blemish-free skin!Our Hydrogel Firming Face Mask Sheet is infused with pure Vitamin C and Centella Asiatica to provide your skin with the nourishment and care it deserves. Say goodbye to dark spots and blemishes as this mask works to brighten and even out your complexion.
With a pack of 10 sheets, you can enjoy the benefits of this powerful mask whenever your skin needs a boost. Whether you’re looking for radiance, relief from blemishes, or just a pampering treat for your skin, the CKD Vita C Teca Blemish Shot Mask has got you covered.
Don’t wait any longer to achieve the glowing, flawless skin you’ve always dreamed of. Try our Hydrogel Firming Face Mask Sheet today and see the difference for yourself! #skincare #vitaminc #centellaasiatica #radiance #blemishfree
#CKD #Vita #Teca #Blemish #Shot #Mask #Hydrogel #Firming #Face #Mask #Sheet #Pure #Vitamin #Centella #Asiatica #Radiance #Relief #Dark #Spots #Blemishes #sheets,centella asiaticaCKD Retino Collagen Guasha Neck Cream 50ml, Korean Cosmetics, Kbeauty, sample
CKD Retino Collagen Guasha Neck Cream 50ml, Korean Cosmetics, Kbeauty, sample
Price : 25.10
Ends on : N/A
View on eBay
Introducing the CKD Retino Collagen Guasha Neck Cream 50ml – Your Ticket to Youthful Skin!Looking for a game-changing neck cream that will leave your skin looking and feeling rejuvenated? Look no further than the CKD Retino Collagen Guasha Neck Cream. This Korean beauty gem is specially formulated with retinol and collagen to target fine lines, wrinkles, and sagging skin on the neck area.
Not only does this cream work wonders on aging skin, but it also comes with a built-in guasha tool for a spa-like massage experience at home. The guasha tool helps to improve blood circulation, promote lymphatic drainage, and sculpt the neck area for a more defined and youthful appearance.
Experience the power of Kbeauty with the CKD Retino Collagen Guasha Neck Cream. Grab your sample today and say hello to firmer, smoother, and more radiant skin! #Kbeauty #CKD #neckcream #youthfulskin #guasha #KoreanCosmetics
#CKD #Retino #Collagen #Guasha #Neck #Cream #50ml #Korean #Cosmetics #Kbeauty #sample,kbeautyCKD Vita C Teca Blemish Shot Mask – Hydrogel Firming Face Mask Sheet with Pure Vitamin C & Centella Asiatica, Radiance, Relief for Dark Spots & Blemishes, 5 sheets
Price: $25.00
(as of Jan 24,2025 04:59:27 UTC – Details)
For external use only.
Product Dimensions : 6.3 x 7 x 0.2 inches; 9.91 ounces
Manufacturer : IMINE CO.,LTD.
ASIN : B0D1TXKNYJ
Country of Origin : Korea, Republic ofINTENSIVE HYDRATION AND FIRMING: Experience a new level of skin rejuvenation with the Vita C Teca Blemish Shot Mask. This hydrogel mask sheet delivers 99% pure vitamin C directly to your skin, enhancing firmness and hydration. Ideal for revitalizing tired and dull skin, this mask ensures lasting moisture retention even after removal.
TARGETED BLEMISH CONTROL: Effective within just two weeks, our mask helps reduce the appearance of dark spots, blemishes, and pigmentation, while also smoothing uneven skin textures. Achieve a clearer, more refined complexion with regular use, designed to bring out your skin’s natural brightness without harsh chemicals.
POWERFUL BLEND OF ACTIVE INGREDIENTS: Packed with a high-performance mix of Cica, vitamin C, arbutin, glutathione, and tranexamic acid, this mask actively fights the root causes of skin discoloration and dullness. Each ingredient is carefully chosen to support skin health and promote a balanced, even skin tone.
FORMULATED FOR DULL AND UNEVEN SKIN TONES: The Vita C Teca Blemish Shot Mask is specially designed for those struggling with dull and uneven skin tones. This mask utilizes a unique blend of ingredients to provide clarity and a smoother texture, reviving your skin’s youthful radiance.
EASY APPLICATION PROCESS: For optimal results, use the mask after cleansing and toning. Apply the two-part mask to your face, and leave it until it turns transparent, indicating full absorption of the active ingredients. Remove the mask and pat in any remaining essence to maximize benefits. Suitable for use before sleep or as a preparatory step in your skincare routine.
Introducing the CKD Vita C Teca Blemish Shot Mask – your secret weapon for achieving radiant, clear skin!Our Hydrogel Firming Face Mask Sheets are infused with Pure Vitamin C and Centella Asiatica, two powerful ingredients known for their brightening and healing properties. Say goodbye to dark spots and blemishes as this mask works to provide relief and even out your skin tone.
Each pack contains 5 sheets of this luxurious mask, perfect for treating yourself to a spa-like experience at home. Simply apply the mask to your cleansed face, sit back, and relax as it works its magic. You’ll be left with a glowing complexion that exudes confidence.
Don’t let blemishes hold you back – try the CKD Vita C Teca Blemish Shot Mask today and discover the power of Vitamin C and Centella Asiatica for yourself! #ClearSkinJourney #RadiantComplexion #SkincareEssentials
#CKD #Vita #Teca #Blemish #Shot #Mask #Hydrogel #Firming #Face #Mask #Sheet #Pure #Vitamin #Centella #Asiatica #Radiance #Relief #Dark #Spots #Blemishes #sheets,centella asiatica
