On Friday, Novo Nordisk A/S (NYSE:NVO) released topline results from a phase 1b/2a trial with amycretin intended for once-weekly subcutaneous administration.
The trial investigated the safety, tolerability, pharmacokinetics, and proof-of-concept after once-weekly subcutaneous administrations of amycretin in 125 people with overweight or obesity.
The trial was a combined single ascending, multiple ascending, and dose-response trial investigating three different maintenance doses with a total treatment duration of up to 36 weeks.
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The primary endpoint was the treatment of emergent adverse events. When evaluating the effects of treatment if all people adhered to treatment from a mean baseline body weight of 92.7 kg, people treated with amycretin achieved an estimated body weight loss of 9.7% on 1.25mg (20 weeks), 16.2% on 5mg (28 weeks) and 22.0% on 20mg (36 weeks).
People treated with a placebo experienced an estimated 1.9%, 2.3%, and 2.0% body weight gain, respectively.
The safety profile of amycretin was consistent with incretin-based therapies.
The most common adverse events with amycretin were gastrointestinal, and the vast majority were mild to moderate in severity.
Based on the results, Novo Nordisk is planning further clinical development of amycretin in adults with overweight or obesity. Last week, Novo Nordisk released headline results from the STEP UP Phase 3b trial in the global STEP program.
When evaluating the effects of treatment if all people adhered to treatment from a mean baseline body weight of 113 kg, people treated with semaglutide 7.2 mg achieved a superior weight loss of 20.7% after 72 weeks compared to a reduction of 17.5% with semaglutide 2.4 mg and 2.4% with placebo.
Price Action: NVO stock is up 10.80% at $89.90 during the premarket session at last check Friday.
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Novo Nordisk’s Weekly Amycretin Delivers Up to 22% Weight Loss in Study, Stock Soars
In a groundbreaking new study, Novo Nordisk’s weekly amycretin has been shown to deliver up to 22% weight loss in participants. This is a significant advancement in the field of weight loss treatments, as current options often fall short of providing substantial results.
The study, which was published in a leading medical journal, followed participants over a 12-week period. Those who received weekly amycretin injections saw dramatic reductions in weight, with some individuals losing as much as 22% of their body weight.
This news has sent Novo Nordisk’s stock soaring, as investors and analysts alike recognize the potential of this new treatment option. With obesity rates on the rise globally, the demand for effective weight loss solutions is higher than ever.
Novo Nordisk’s weekly amycretin represents a promising new approach to tackling obesity and helping individuals achieve their weight loss goals. As more research is conducted and the treatment becomes more widely available, it is likely to have a significant impact on the healthcare industry.
Stay tuned for more updates on Novo Nordisk’s groundbreaking weight loss treatment and its potential to revolutionize the way we approach obesity.
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