Zion Tech Group

Tag: Disorder

  • Largest Genetic Study of Bipolar Disorder Identifies 298 Regions of the Genome That Increase Risk for the Condition


    UNDER EMBARGO UNTIL
    January 22 at 11:00 AM EST
    Media Contact: Elizabeth Dowling
    Mount Sinai Press Office
    347-541-0212
    [email protected] 

    Largest Genetic Study of Bipolar Disorder Identifies 298 Regions of the Genome That Increase Risk for the Condition
    Findings represent a four-fold increase over the last genome-wide association study conducted by an international consortium of leading psychiatric researchers

    Newswise — In the largest genome-wide study of bipolar disorder to date, an international team of psychiatric genetics researchers has identified 298 regions of the genome containing DNA variations that increase risk for the disorder—a more than four-fold increase over the number previously identified, according to research published in Nature  [https://doi.org/10.1038/s41586-024-08468-9] on Wednesday, January 22. 

    The study—the first large multi-ancestry genomic analysis of the disorder to include data from people of European, East Asian, African American, and Latino ancestries—also identifies a new region associated with an increased risk for the disorder within the East Asian samples. Cross-referencing a range of methods, including fine-mapping and other variant-to-gene-mapping approaches, the team identified 36 genes suspected to be relevant to bipolar disorder. Bipolar disorder is an often lifelong mood disorder that impairs quality of life and functional ability, and is associated with suicidality. It affects an estimated 40-50 million people worldwide. Bipolar disorder is clinically heterogeneous, encompassing distinct subtypes 1 and 2. Bipolar disorder type 1 is characterized by episodes of both mania and depression, while bipolar disorder type 2 includes episodes of hypomania (a less severe form of mania) and depression. Despite the prevalence of bipolar disorder, it can take an average of eight years to get a proper diagnosis, and much remains unknown about the biology of the condition.

    To help elucidate bipolar disorder’s underlying biology, an international team of scientists from within the Psychiatric Genomics Consortium conducted a genome-wide association study, scanning the DNA of 2.9 million study participants from cohorts worldwide to identify genetic markers that were more common in those with the condition. This involved scanning more than 6.7 million common variations in the DNA sequences among the study participants, more than 158,000 of whom experience bipolar disorder.

    “It is well established that bipolar disorder has a substantial genetic basis, so identifying DNA variations that increase risk is of paramount importance to understanding the condition’s genetic architecture. In addition to identifying 298 regions of the genome that contain variations that increase risk for bipolar disorder, the 36 key genes we identified as being linked to the condition can now be followed up in a range of experiments to uncover the biological mechanisms through which each relates to the disorder,” says Niamh Mullins, PhD, Assistant Professor of Psychiatry, and Genetics and Genomic Sciences, at the Icahn School of Medicine at Mount Sinai and one of the senior authors of the paper. “The newly identified genes may also be used in experiments to explore new drug targets and drug development for bipolar disorder.”

    The study team also found differences in the genetic characteristics of bipolar disorder between clinical (patients recruited from hospital inpatient or outpatient units), community-based (participants in general population biobanks), and self-reporting (participants in online personal health surveys) participants. These genetic differences are likely to be driven by a higher prevalence of bipolar subtype 1 in the clinical samples versus a higher prevalence of bipolar subtype 2 in the self-reporting samples, which highlights the need for researchers to be mindful of the data-gathering strategies used within their studies of the condition.

    According to the research team, the genetic signal of bipolar disorder is related to specific brain cell types, including GABAergic interneurons and medium spiny neurons, in the prefrontal cortex and hippocampus. They also found that cells in the intestine and pancreas are involved, although more research is necessary to further understand this biology. 

    “Although this work does not immediately impact patient care, it opens the possibilities for long-term positive impact for patients and their families who are impacted by this widespread disorder,” said Ole Andreassen, MD, PhD, Professor of Psychiatry at the Institute of Clinical Medicine and Oslo University Hospital, and senior author of the paper. “Our research paves the way for the development of improved treatments, earlier interventions, and precision medicine approaches that will support clinicians in their decision-making to enable them to manage the condition in the most effective way for each patient.”

    The Psychiatric Genomics Consortium (PGC) is an international consortium of scientists dedicated to studying the genetic basis of psychiatric disorders and includes more than 1,700 researchers from over 65 countries.

    ”This research would not have been possible without the collaborative efforts of scientists worldwide that enabled the study of hundreds of thousands of DNA sequences,” said Kevin O’Connell, PhD, researcher at the University of Oslo and first author of the paper.

    About the Mount Sinai Health System
    Mount Sinai Health System is one of the largest academic medical systems in the New York metro area, with 48,000 employees working across eight hospitals, more than 400 outpatient practices, more than 600 research and clinical labs, a school of nursing, and a leading school of medicine and graduate education. Mount Sinai advances health for all people, everywhere, by taking on the most complex health care challenges of our time—discovering and applying new scientific learning and knowledge; developing safer, more effective treatments; educating the next generation of medical leaders and innovators; and supporting local communities by delivering high-quality care to all who need it.

    Through the integration of its hospitals, labs, and schools, Mount Sinai offers comprehensive health care solutions from birth through geriatrics, leveraging innovative approaches such as artificial intelligence and informatics while keeping patients’ medical and emotional needs at the center of all treatment. The Health System includes approximately 9,000 primary and specialty care physicians and 11 free-standing joint-venture centers throughout the five boroughs of New York City, Westchester, Long Island, and Florida. Hospitals within the System are consistently ranked by Newsweek’s® “The World’s Best Smart Hospitals, Best in State Hospitals, World Best Hospitals and Best Specialty Hospitals” and by U.S. News & World Report‘s® “Best Hospitals” and “Best Children’s Hospitals.” The Mount Sinai Hospital is on the U.S. News & World Report® “Best Hospitals” Honor Roll for 2024-2025.

    For more information, visit https://www.mountsinai.org or find Mount Sinai on Facebook, Twitter and YouTube.

    ###





    A groundbreaking study has revealed new insights into the genetic factors underlying bipolar disorder, a complex and often debilitating mental health condition. The largest genetic study of bipolar disorder to date has identified 298 regions of the genome that increase the risk for developing the disorder.

    Researchers from around the world analyzed genetic data from over 40,000 individuals with bipolar disorder and more than 60,000 controls without the condition. By comparing the genetic profiles of these two groups, the researchers were able to pinpoint specific regions of the genome that are associated with an increased risk for bipolar disorder.

    The study, published in the journal Nature Genetics, sheds light on the genetic architecture of bipolar disorder and provides valuable information that could help researchers better understand the underlying mechanisms of the condition. By identifying these genetic risk factors, researchers hope to develop more targeted and effective treatments for individuals with bipolar disorder.

    This groundbreaking study represents a major step forward in our understanding of the genetic basis of bipolar disorder. By identifying these 298 regions of the genome that increase the risk for the condition, researchers are paving the way for new discoveries and potential breakthroughs in the treatment of this complex disorder.

    Tags:

    1. Bipolar disorder genetic study
    2. Genetic risk factors for bipolar disorder
    3. Genome regions and bipolar disorder
    4. Bipolar disorder genetic research findings
    5. Bipolar disorder risk factors
    6. Genetic study on bipolar disorder
    7. Bipolar disorder genetic markers
    8. Bipolar disorder genome regions
    9. Bipolar disorder genetic predisposition
    10. Bipolar disorder genetic analysis

    #Largest #Genetic #Study #Bipolar #Disorder #Identifies #Regions #Genome #Increase #Risk #Condition

  • Researchers identify 36 genes related to the onset and development of bipolar disorder


    The study was led by the Bipolar Disorder Working Group at the Psychiatric Genomics Consortium, an international group made up of more than 800 researchers from 40 countries in which professionals from IDIBAPS-Hospital Clínic and Hospital Vall d’Hebron participate, all of them researchers from CIBER de Salud Mental (CIBERSAM).

    A disorder with a high genetic component

    Bipolar disorder is a chronic mental disorder that affects between 40 and 50 million people worldwide and is characterised by the alternation of depressive episodes and episodes of mania or hypomania (euphoric or irritable moods). It can have a profound impact on daily life if not treated properly and poses a significant public health problem.

    It has a substantial genetic basis, with an estimated heritability of between 60% and 80%. However, identifying the specific genes involved in this disorder has been a great challenge due to its complexity, as it combines genetic and environmental factors.

    Genetic characterisation of bipolar disorder

    The international group conducted a meta-analysis of several genome-wide association studies, combining their results to more accurately identify the genetic variants associated with a disease or a trait. In total, more than 158,000 patients with bipolar disorder and 2.8 million people without the disorder were included and the genes of the two groups were compared to decipher the existing differences. The most important feature is that people from all six inhabitable continents were included for the first time.

    The study identified 337 variants of genome-wide significance (GWS) that are mutually independent and grouped into 298 specific regions of the genome (loci). This identification is four times larger than that of any previous study. These genetic variants are related to the causes of the disorder, as well as to brain plasticity and signal transmission.

    By combining the results of advanced genetic mapping techniques, like fine-mapping and other strategies to link genetic variants with specific genes, the researchers identified 36 reliable genes related to the causes or development of bipolar disorder.

    The researchers also found genetic differences, depending on the patients’ subtype of bipolar disorder. For instance, they found a greater genetic relationship with schizophrenia in the cohorts with a large proportion of patients with type 1 bipolar disorder. In the cohort with more cases of patients with type 2 bipolar disorder, they detected a greater genetic correlation with major depressive disorder and attention deficit hyperactivity disorder (ADHD).

    ‘With this study, we have taken a big step forward to better understand how this disorder functions and what causes it. Given a little more time, we also hope to develop new and better treatments for it’, says Dr Eduard Vieta, the head of Hospital Clínic’s Psychiatry Service and of the IDIBAPS research group Bipolar and depressive disorders.

    Study reference:

    Characterising the genetic landscape of bipolar disorder yields novel biological insights. Nature. DOI: https://www.nature.com/articles/s41586-024-08468-9



    Researchers have recently made a breakthrough in understanding bipolar disorder by identifying 36 genes that are related to the onset and development of the disorder. This discovery sheds light on the complex genetic factors that contribute to bipolar disorder and may lead to new avenues for treatment and management.

    Bipolar disorder is a mental health condition characterized by extreme mood swings, ranging from manic episodes of high energy and euphoria to depressive episodes of sadness and hopelessness. It affects millions of people worldwide and can have a significant impact on daily functioning and quality of life.

    By pinpointing these 36 genes, researchers have taken a crucial step towards unraveling the genetic basis of bipolar disorder. Understanding the role of these genes in the development of the disorder could help identify individuals at risk, improve early detection, and ultimately lead to more targeted and effective treatments.

    This groundbreaking research opens up new possibilities for personalized medicine and precision psychiatry in the treatment of bipolar disorder. As scientists continue to delve deeper into the genetic underpinnings of mental health conditions, we are one step closer to developing more tailored and effective interventions for those living with bipolar disorder.

    Tags:

    1. Bipolar disorder genes
    2. Genetic factors in bipolar disorder
    3. Bipolar disorder research
    4. Bipolar disorder genetics study
    5. Genetic markers for bipolar disorder
    6. Bipolar disorder gene identification
    7. Genes linked to bipolar disorder
    8. Bipolar disorder genetic research
    9. Bipolar disorder gene discovery
    10. Genetic variations in bipolar disorder

    #Researchers #identify #genes #related #onset #development #bipolar #disorder

  • Genomics yields biological and phenotypic insights into bipolar disorder


  • Division of Mental Health and Addiction, Oslo University Hospital, Oslo, Norway

    Kevin S. O’Connell, Elise Koch, Nadine Parker, Oleksandr Frei, Alexey Shadrin, Olav B. Smeland, Markos Tesfaye, Martin Tesli, Ingrid Melle & Ole A. Andreassen

  • Center for Precision Psychiatry, University of Oslo, Oslo, Norway

    Kevin S. O’Connell, Elise Koch, Nadine Parker, Ole Kristian Drange, Alexey Shadrin, Olav B. Smeland, Markos Tesfaye, Martin Tesli & Ole A. Andreassen

  • Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, USA

    Maria Koromina, Jaroslav Bendl, Tereza Clarence, John F. Fullard, Jessica S. Johnson, Dolores Malaspina, Laura G. Sloofman, René S. Kahn, Panos Roussos, Eli A. Stahl & Niamh Mullins

  • Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA

    Maria Koromina & Niamh Mullins

  • Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA

    Maria Koromina, Jaroslav Bendl, Tereza Clarence, John F. Fullard, Jessica S. Johnson, Dolores Malaspina, Laura G. Sloofman, Panos Roussos, Eli A. Stahl & Niamh Mullins

  • Division of Psychiatry, University College London, London, UK

    Tracey van der Veen, Nicholas Bass, Andrew McQuillin & Tracey van der Veen

  • Department of Human Genetics, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, USA

    Toni Boltz & Roel A. Ophoff

  • Institute of Human Genetics, University of Bonn, School of Medicine and University Hospital Bonn, Bonn, Germany

    Friederike S. David, Eva C. Beins, Isabelle Claus, Franziska Degenhardt, Stefan Herms, Per Hoffmann, Eva C. Schulte, Lisa Sindermann, Sven Cichon, Markus M. Nöthen & Andreas J. Forstner

  • Department of Psychiatry and Psychotherapy, University of Marburg, Marburg, Germany

    Friederike S. David, Frederike Stein & Tilo Kircher

  • Centre for Neuropsychiatric Genetics and Genomics, Division of Psychological Medicine and Clinical Neurosciences, Cardiff University, Cardiff, UK

    Jessica Mei Kay Yang, Valentina Escott-Price, Liz Forty, Peter A. Holmans, Antonio F. Pardiñas, James T. R. Walters, Nicholas Craddock, Ian Jones, George Kirov, Michael C. O’Donovan, Michael J. Owen & Arianna Di Florio

  • 23andMe Inc., Sunnyvale, CA, USA

    Keng-Han Lin & Xin Wang

  • Social, Genetic and Developmental Psychiatry Centre, King’s College London, London, UK

    Jonathan R. I. Coleman, Gerome Breen & Panagiotis Ferentinos

  • NIHR Maudsley BRC, King’s College London, London, UK

    Jonathan R. I. Coleman & Gerome Breen

  • Mental Health and Neuroscience, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia

    Brittany L. Mitchell, Penelope A. Lind, Jackson G. Thorp & Sarah E. Medland

  • School of Biomedical Sciences and Faculty of Medicine, The University of Queensland, Brisbane, Queensland, Australia

    Brittany L. Mitchell & Penelope A. Lind

  • New York University, New York, NY, USA

    Caroline C. McGrouther & Aaditya V. Rangan

  • Flatiron Institute, New York, NY, USA

    Aaditya V. Rangan

  • School of Biomedical Sciences, Queensland University of Technology, Brisbane, Queensland, Australia

    Penelope A. Lind

  • Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden

    Arvid Harder, Dennis Hellgren, Mikael Landén & Patrick F. Sullivan

  • Center for Disease Neurogenomics, Icahn School of Medicine at Mount Sinai, New York, NY, USA

    Jaroslav Bendl, Tereza Clarence, John F. Fullard & Panos Roussos

  • Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA

    Jaroslav Bendl, Tereza Clarence, John F. Fullard & Panos Roussos

  • Institute of Psychiatric Phenomics and Genomics (IPPG), LMU University Hospital, LMU Munich, Munich, Germany

    Kristina Adorjan, Monika Budde, Urs Heilbronner, Janos L. Kalman, Sergi Papiol, Eva C. Schulte, Fanny Senner & Thomas G. Schulze

  • Department of Psychiatry and Psychotherapy, University Hospital, LMU Munich, Munich, Germany

    Kristina Adorjan, Janos L. Kalman, Sergi Papiol & Fanny Senner

  • University Hospital of Psychiatry and Psychotherapy, University of Bern, Bern, Switzerland

    Kristina Adorjan

  • iPSYCH, The Lundbeck Foundation Initiative for Integrative Psychiatric Research, Aarhus, Denmark

    Esben Agerbo, Thomas D. Als, Carsten Bøcker Pedersen, Jonas Bybjerg-Grauholm, Jakob Grove, Manuel Mattheisen, Anders D. Børglum, David M. Hougaard, Ole Mors, Preben Bo Mortensen, Merete Nordentoft & Thomas Werge

  • National Centre for Register-Based Research, Aarhus University, Aarhus, Denmark

    Esben Agerbo & Carsten Bøcker Pedersen

  • Centre for Integrated Register-based Research, Aarhus University, Aarhus, Denmark

    Esben Agerbo & Carsten Bøcker Pedersen

  • Department of Neuroscience, Istituto Di Ricerche Farmacologiche Mario Negri IRCCS, Milano, Italy

    Diego Albani

  • Instituto de Salud Carlos III, Biomedical Network Research Centre on Mental Health (CIBERSAM), Madrid, Spain

    Silvia Alemany, Rosa Bosch, Judit Cabana-Domínguez, Sergi Papiol, Maria Soler Artigas, Josep Antoni Ramos-Quiroga & Marta Ribasés

  • Department of Psychiatry, Hospital Universitari Vall d’Hebron, Barcelona, Spain

    Silvia Alemany, Judit Cabana-Domínguez, Maria Soler Artigas, Josep Antoni Ramos-Quiroga & Marta Ribasés

  • Psychiatric Genetics Unit, Group of Psychiatry Mental Health and Addictions, Vall d’Hebron Research Institut (VHIR), Universitat Autònoma de Barcelona, Barcelona, Spain

    Silvia Alemany, Judit Cabana-Domínguez, Maria Soler Artigas, Josep Antoni Ramos-Quiroga & Marta Ribasés

  • Department of Psychiatry and Behavioral Neuroscience, University of Chicago, Chicago, IL, USA

    Ney Alliey-Rodriguez & Elliot S. Gershon

  • Northwestern University, Chicago, IL, USA

    Ney Alliey-Rodriguez

  • iSEQ, Center for Integrative Sequencing, Aarhus University, Aarhus, Denmark

    Thomas D. Als & Manuel Mattheisen

  • Department of Biomedicine-Human Genetics, Aarhus University, Aarhus, Denmark

    Thomas D. Als & Manuel Mattheisen

  • Department of Neurology, Klinikum rechts der Isar, School of Medicine, Technical University of Munich, Munich, Germany

    Till F. M. Andlauer

  • National and Kapodistrian University of Athens, 2nd Department of Psychiatry, Attikon General Hospital, Athens, Greece

    Anastasia Antoniou, Konstantinos Dafnas & Panagiotis Ferentinos

  • PsychGen Centre for Genetic Epidemiology and Mental Health, Norwegian Institute of Public Health, Oslo, Norway

    Helga Ask, Elizabeth C. Corfield & Alexandra Havdahl

  • PROMENTA Research Centre, Department of Psychology, University of Oslo, Oslo, Norway

    Helga Ask & Alexandra Havdahl

  • Department of Psychiatry and Psychotherapy, University Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany

    Michael Bauer & Andrea Pfennig

  • Department of Psychiatry and Behavioral Sciences, SUNY Downstate Health Sciences University, Brooklyn, NY, USA

    Tim B. Bigdeli & Chris Chatzinakos

  • VA NY Harbor Healthcare System, Brooklyn, NY, USA

    Tim B. Bigdeli

  • Institute for Genomics in Health, SUNY Downstate Health Sciences University, Brooklyn, NY, USA

    Tim B. Bigdeli & Chris Chatzinakos

  • Department of Epidemiology and Biostatistics, School of Public Health, SUNY Downstate Health Sciences University, Brooklyn, NY, USA

    Tim B. Bigdeli

  • Psychiatry, Brain Center UMC Utrecht, Utrecht, The Netherlands

    Marco P. Boks, Annabel Vreeker & René S. Kahn

  • Research and Communication Unit for Musculoskeletal Health, Division of Clinical Neuroscience, Oslo University Hospital, Ullevål, Oslo, Norway

    Sigrid Børte

  • Institute of Clinical Medicine, University of Oslo, Oslo, Norway

    Sigrid Børte, Oleksandr Frei & John-Anker Zwart

  • HUNT Center for Molecular and Clinical Epidemiology, Department of Public Health and Nursing, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology, Trondheim, Norway

    Sigrid Børte, Bendik S. Winsvold & John-Anker Zwart

  • Programa SJD MIND Escoles, Hospital Sant Joan de Déu, Institut de Recerca Sant Joan de Déu, Esplugues de Llobregat, Spain

    Rosa Bosch & Miquel Casas

  • Department of Psychiatry, Psychosomatic Medicine and Psychotherapy, University Hospital Frankfurt, Frankfurt am Main, Germany

    Murielle Brum, Nathalie Brunkhorst-Kanaan, Thorsten M. Kranz & Andreas Reif

  • K. G. Jebsen Center for Genetic Epidemiology, Department of Public Health and Nursing, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology, Trondheim, Norway

    Ben M. Brumpton & Kristian Hveem

  • Center for Neonatal Screening, Department for Congenital Disorders, Statens Serum Institut, Copenhagen, Denmark

    Jonas Bybjerg-Grauholm & David M. Hougaard

  • Psychiatry, University of California San Francisco, San Francisco, CA, USA

    William Byerley

  • School of Biomedical Sciences and Pharmacy, The University of Newcastle, Callaghan, New South Wales, Australia

    Murray J. Cairns

  • Precision Medicine Research Program, Hunter Medical Research Institute, New Lambton, New South Wales, Australia

    Murray J. Cairns

  • Section of Psychiatry, Department of Medical Sciences and Public Health, University of Cagliari, Cagliari, Italy

    Bernardo Carpiniello & Mirko Manchia

  • Department of Psychiatry and Forensic Medicine, Universitat Autònoma de Barcelona, Barcelona, Spain

    Miquel Casas & Josep Antoni Ramos-Quiroga

  • Fundació Privada d’Investigació Sant Pau (FISP), Barcelona, Spain

    Miquel Casas

  • Department of Psychiatry, Mood Disorders Program, McGill University Health Center, Montreal, Québec, Canada

    Pablo Cervantes & Cristiana Cruceanu

  • Department of Psychiatry, National Taiwan University Hospital, Taipei, Taiwan

    Hsi-Chung Chen & Po-Hsiu Kuo

  • Department of Psychiatry, College of Medicine, National Taiwan University, Taipei, Taiwan

    Hsi-Chung Chen

  • Division of Psychiatry, University of Edinburgh, Edinburgh, UK

    Toni-Kim Clarke

  • Department of Quantitative Health Sciences Research, Mayo Clinic, Rochester, MN, USA

    Brandon Coombes & Joanna M. Biernacka

  • Nic Waals Institute, Lovisenberg Diaconal Hospital, Oslo, Norway

    Elizabeth C. Corfield & Alexandra Havdahl

  • Department of Genetics and Bioinformatics, Norwegian Institute of Public Health, Oslo, Norway

    Elizabeth C. Corfield

  • Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden

    Cristiana Cruceanu

  • Department of Psychiatry, Universidad Autonoma de Nuevo Leon, Monterrey, Mexico

    Alfredo Cuellar-Barboza

  • Department of Psychiatry and Psychology, Mayo Clinic, Rochester, MN, USA

    Alfredo Cuellar-Barboza, Joanna M. Biernacka & Mark Frye

  • Department of Psychiatry, Laboratory of Psychiatric Genetics, Poznan University of Medical Sciences, Poznan, Poland

    Piotr M. Czerski

  • Center for Multimodal Imaging and Genetics, Departments of Neurosciences, Radiology, and Psychiatry, University of California, San Diego, CA, USA

    Anders M. Dale

  • Division of Psychiatry and Psychotherapeutic Medicine, Medical University of Graz, Graz, Austria

    Nina Dalkner, Frederike T. Fellendorf, Susanne Bengesser & Eva Z. Reininghaus

  • Department of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, University Hospital Essen, University of Duisburg-Essen, Duisburg, Germany

    Franziska Degenhardt

  • Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD, USA

    J. Raymond DePaulo, James B. Potash, Peter P. Zandi, Fernando S. Goes & Thomas G. Schulze

  • Department of Medical Genetics, Oslo University Hospital Ullevål, Oslo, Norway

    Srdjan Djurovic

  • Department of Clinical Science, University of Bergen, Bergen, Norway

    Srdjan Djurovic & Markos Tesfaye

  • Department of Psychiatry, Sørlandet Hospital, Kristiansand, Norway

    Ole Kristian Drange

  • Department of Psychiatry, University of Arizona College of Medicine-Phoenix, Phoenix, AZ, USA

    Ayman H. Fanous

  • Carl T. Hayden Veterans Affairs Medical Center, Phoenix, AZ, USA

    Ayman H. Fanous

  • Banner-University Medical Center, Phoenix, AZ, USA

    Ayman H. Fanous

  • Academic Psychiatry, Newcastle University, Newcastle upon Tyne, UK

    I. Nicol Ferrier

  • Department of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany

    Josef Frank, Lea Sirignano, Stephanie H. Witt, Lea Zillich, Marcella Rietschel, Thomas G. Schulze & Fabian Streit

  • Center for Neurobehavioral Genetics, Semel Institute for Neuroscience and Human Behavior, Los Angeles, CA, USA

    Nelson B. Freimer & Roel A. Ophoff

  • Department of Psychiatry and Biobehavioral Science, Semel Institute, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, USA

    Nelson B. Freimer & Roel A. Ophoff

  • Department of Psychiatry, Dalhousie University, Halifax, Nova Scotia, Canada

    Julie Garnham, Claire O’Donovan, Claire Slaney, Evangelia Eirini Tsermpini & Martin Alda

  • Department of Psychological Sciences, University of Missouri, Columbia, MO, USA

    Ian R. Gizer

  • Genetics and Computational Biology, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia

    Scott D. Gordon & Nicholas G. Martin

  • Psychological Medicine, University of Worcester, Worcester, UK

    Katherine Gordon-Smith, Amy Perry & Lisa A. Jones

  • Department of Psychiatry, University of California San Diego, La Jolla, CA, USA

    Tiffany A. Greenwood, Adam X. Maihofer, Paul D. Shilling, John R. Kelsoe & Caroline M. Nievergelt

  • Department of Biomedicine and the iSEQ Center, Aarhus University, Aarhus, Denmark

    Jakob Grove & Anders D. Børglum

  • Center for Genomics and Personalized Medicine, CGPM, Aarhus, Denmark

    Jakob Grove & Anders D. Børglum

  • Bioinformatics Research Centre, Aarhus University, Aarhus, Denmark

    Jakob Grove

  • Mental Health Department, University Regional Hospital, Biomedicine Institute (IBIMA), Málaga, Spain

    José Guzman-Parra & Fermin Mayoral

  • Department of Neuropsychiatry, Seoul National University Bundang Hospital, Seongnam, Republic of Korea

    Tae Hyon Ha, Euitae Kim, Jaeyoung Kim, Hye Youn Park & Woojae Myung

  • Department of Neuropsychiatry, Seoul National University College of Medicine, Seoul, Republic of Korea

    Tae Hyon Ha, Euitae Kim, Hye Youn Park & Woojae Myung

  • Institute for Translational Psychiatry, University of Münster, Münster, Germany

    Tim Hahn & Udo Dannlowski

  • Faculty of Medicine, Department of Psychiatry, School of Health Sciences, University of Iceland, Reykjavik, Iceland

    Magnus Haraldsson & Engilbert Sigurdsson

  • Landspitali University Hospital, Reykjavik, Iceland

    Magnus Haraldsson & Engilbert Sigurdsson

  • Department of Psychology, Eberhard Karls Universität Tübingen, Tubingen, Germany

    Martin Hautzinger

  • Department of Biomedicine, University of Basel, Basel, Switzerland

    Stefan Herms, Per Hoffmann, Thomas W. Mühleisen & Sven Cichon

  • Institute of Medical Genetics and Pathology, University Hospital Basel, Basel, Switzerland

    Stefan Herms, Per Hoffmann & Sven Cichon

  • Brain and Mind Centre, The University of Sydney, Sydney, New South Wales, Australia

    Ian B. Hickie

  • Department of Psychiatry, Taipei City Psychiatric Center, Taipei City Hospital, Taipei, Taiwan

    Ming-Chyi Huang

  • Department of Psychiatry, Nagoya University Graduate School of Medicine, Nagoya, Japan

    Masashi Ikeda

  • Department of Psychiatry, Fujita Health University School of Medicine, Toyoake, Japan

    Masashi Ikeda, Nakao Iwata & Takeo Saito

  • Université Paris Est Créteil, INSERM, IMRB, Translational Neuropsychiatry, Créteil, France

    Stéphane Jamain & Marion Leboyer

  • Department of Psychiatry, UNC Chapel Hill School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA

    Jessica S. Johnson

  • Institute of Neuroscience and Physiology, University of Gothenburg, Gothenburg, Sweden

    Lina Jonsson & Mikael Landén

  • Laboratory of Complex Trait Genomics, Department of Computational Biology and Medical Sciences, Graduate School of Frontier Sciences, The University of Tokyo, Tokyo, Japan

    Yoichiro Kamatani

  • Laboratory for Statistical and Translational Genetics, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan

    Yoichiro Kamatani & Chikashi Terao

  • Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, Toronto, Ontario, Canada

    James L. Kennedy & John B. Vincent

  • Neurogenetics Section, Centre for Addiction and Mental Health, Toronto, Ontario, Canada

    James L. Kennedy

  • Department of Psychiatry, University of Toronto, Toronto, Ontario, Canada

    James L. Kennedy

  • Institute of Medical Sciences, University of Toronto, Toronto, Ontario, Canada

    James L. Kennedy

  • Department of Brain and Cognitive Sciences, Seoul National University College of Natural Sciences, Seoul, Republic of Korea

    Euitae Kim

  • Samsung Advanced Institute for Health Sciences and Technology (SAIHST), Sungkyunkwan University, Samsung Medical Center, Seoul, Republic of Korea

    Jaeyoung Kim & Hong-Hee Won

  • Department of Psychiatry and Neurobehavioral Science, University College Cork, Cork, Ireland

    Sarah Kittel-Schneider

  • Department of Psychiatry, Psychosomatics and Psychotherapy, Center of Mental Health, University Hospital Würzburg, Würzburg, Germany

    Sarah Kittel-Schneider, Manuel Mattheisen & Micha Gawlik

  • Human Genetics Institute of New Jersey, Rutgers University, Piscataway, NJ, USA

    James A. Knowles

  • ISGlobal, Barcelona, Spain

    Manolis Kogevinas

  • Estonian Genome Centre, Institute of Genomics, University of Tartu, Tartu, Estonia

    Kristi Krebs & Lili Milani

  • Department of Psychiatry, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands

    Steven A. Kushner

  • Translational Psychiatry, Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden

    Catharina Lavebratt, Martin Lundberg, Vincent Millischer, Lena Backlund & Martin Schalling

  • Center for Molecular Medicine, Karolinska University Hospital, Stockholm, Sweden

    Catharina Lavebratt, Martin Lundberg, Vincent Millischer, Lena Backlund & Martin Schalling

  • Psychiatry, North East London NHS Foundation Trust, Ilford, UK

    Jacob Lawrence

  • Clinic for Psychiatry and Psychotherapy, University Hospital Cologne, Cologne, Germany

    Markus Leber

  • Department of Psychiatry, Korea University College of Medicine, Seoul, Republic of Korea

    Heon-Jeong Lee

  • Analytic and Translational Genetics Unit, Massachusetts General Hospital, Boston, MA, USA

    Calwing Liao, Robert Ye, Benjamin M. Neale & Stephan Ripke

  • Stanley Center for Psychiatric Research, Broad Institute, Cambridge, MA, USA

    Calwing Liao, Robert Ye, Benjamin M. Neale, Stephan Ripke & Jordan W. Smoller

  • Department of Translational Research in Psychiatry, Max Planck Institute of Psychiatry, Munich, Germany

    Susanne Lucae & Bertram Müller-Myhsok

  • Division of Psychiatry, Centre for Clinical Brain Sciences, The University of Edinburgh, Edinburgh, UK

    Donald J. MacIntyre & Andrew M. McIntosh

  • Department of Psychiatry and Psychotherapy, University of Bonn, School of Medicine and University Hospital Bonn, Bonn, Germany

    Wolfgang Maier & Eva C. Schulte

  • Research/Psychiatry, Veterans Affairs San Diego Healthcare System, San Diego, CA, USA

    Adam X. Maihofer & Caroline M. Nievergelt

  • Unit of Clinical Psychiatry, University Hospital Agency of Cagliari, Cagliari, Italy

    Mirko Manchia

  • National and Kapodistrian University of Athens, Medical School, Clinical Biochemistry Laboratory, Attikon General Hospital, Athens, Greece

    Eirini Maratou & Paraskevi Moutsatsou

  • Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden

    Lina Martinsson & Tomas Olsson

  • Centre for Psychiatry Research, SLSO Region Stockholm, Stockholm, Sweden

    Lina Martinsson

  • Department of Clinical Neuroscience, Centre for Psychiatry Research, Karolinska Institutet, Stockholm, Sweden

    Manuel Mattheisen

  • Human and Systems Genetics Working Group, Department of Genetics, Stellenbosch University, Stellenbosch, South Africa

    Nathaniel W. McGregor

  • Department of Psychiatry, University of Michigan, Ann Arbor, MI, USA

    Melvin G. McInnis

  • Genetic Cancer Susceptibility Group, International Agency for Research on Cancer, Lyon, France

    James D. McKay

  • Institute for Genomic Health, SUNY Downstate Medical Center College of Medicine, Brooklyn, NY, USA

    Helena Medeiros

  • Department of Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany

    Andreas Meyer-Lindenberg & Fabian Streit

  • German Centre for Mental Health (DZPG), partner site Mannheim-Heidelberg-Ulm, Mannheim, Germany

    Andreas Meyer-Lindenberg

  • Department of Psychiatry and Psychotherapy, Clinical Division of General Psychiatry, Medical University of Vienna, Vienna, Austria

    Vincent Millischer

  • Comprehensive Center for Clinical Neurosciences and Mental Health, Medical University of Vienna, Vienna, Austria

    Vincent Millischer

  • Centre for Neuroimaging and Cognitive Genomics (NICOG), School of Biological and Chemical Sciences, University of Galway, Galway, Ireland

    Derek W. Morris

  • Institute of Neuroscience and Medicine (INM-1), Research Centre Jülich, Jülich, Germany

    Thomas W. Mühleisen, Sven Cichon & Andreas J. Forstner

  • Population Health, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia

    Catherine M. Olsen & David C. Whiteman

  • Department of Psychiatry and Psychotherapy, Charité-Universitätsmedizin, Berlin, Germany

    Georgia Panagiotaropoulou & Stephan Ripke

  • Department of Biomedical Sciences, University of Cagliari, Cagliari, Italy

    Claudia Pisanu & Alessio Squassina

  • Oxford Health NHS Foundation Trust, Warneford Hospital, Oxford, UK

    Digby Quested

  • Department of Psychiatry, University of Oxford, Warneford Hospital, Oxford, UK

    Digby Quested

  • Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, GA, USA

    Mark H. Rapaport

  • Outpatient Clinic for Bipolar Disorder, Altrecht, Utrecht, The Netherlands

    Eline J. Regeer

  • Department of Psychiatry, Washington University in Saint Louis, Saint Louis, MO, USA

    John P. Rice

  • Department of Biochemistry and Molecular Biology II, Faculty of Pharmacy, University of Granada, Granada, Spain

    Margarita Rivera

  • Institute of Neurosciences ‘Federico Olóriz’, Biomedical Research Center (CIBM), University of Granada, Granada, Spain

    Margarita Rivera

  • Instituto de Investigación Biosanitaria ibs.GRANADA, Granada, Spain

    Margarita Rivera

  • KG Jebsen Centre for Neurodevelopmental disorders, University of Oslo, Oslo, Norway

    Alexey Shadrin

  • Faculty of Medicine, University of Queensland, Brisbane, Queensland, Australia

    Dan Siskind & Dan Siskind

  • Division of Psychiatry, Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, UK

    Daniel J. Smith

  • Psychiatry and the Behavioral Sciences, University of Southern California, Los Angeles, CA, USA

    Janet L. Sobell

  • Department of Genetics, Microbiology, and Statistics, Faculty of Biology, Universitat de Barcelona, Barcelona, Spain

    Maria Soler Artigas & Marta Ribasés

  • SAMRC Unit on Risk and Resilience in Mental Disorders, Dept of Psychiatry and Neuroscience Institute, University of Cape Town, Cape Town, South Africa

    Dan J. Stein

  • Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, Richmond, VA, USA

    Mei-Hsin Su

  • Human Genetics Branch, Intramural Research Program, National Institute of Mental Health, Bethesda, MD, USA

    Heejong Sung & Francis J. McMahon

  • Department of Environmental Epidemiology, Nofer Institute of Occupational Medicine, Lodz, Poland

    Beata Świątkowska

  • Department of Mental Disorders, Norwegian Institute of Public Health, Oslo, Norway

    Martin Tesli

  • deCODE Genetics/Amgen, Reykjavik, Iceland

    Thorgeir E. Thorgeirsson, Hreinn Stefansson & Kari Stefansson

  • Neuroscience Research Australia, Sydney, New South Wales, Australia

    Claudio Toma, Janice M. Fullerton, Melissa J. Green, Peter R. Schofield, Cynthia S. Weickert & Thomas W. Weickert

  • Discipline of Psychiatry and Mental Health, School of Clinical Medicine, Faculty of Medicine and Health, University of New South Wales, Sydney, New South Wales, Australia

    Claudio Toma, Vaughan J. Carr, Melissa J. Green, Philip B. Mitchell, Cynthia S. Weickert & Thomas W. Weickert

  • Centro de Biología Molecular Severo Ochoa, Universidad Autónoma de Madrid and CSIC, Madrid, Spain

    Claudio Toma

  • Department of Psychiatry, Harvard Medical School, Boston, MA, USA

    Leonardo Tondo

  • School of Biomedical Science and Pharmacy, University of Newcastle, Newcastle, New South Wales, Australia

    Paul A. Tooney

  • Department of Psychiatry, Taipei Veterans General Hospital, Taipei, Taiwan

    Shih-Jen Tsai

  • Division of Psychiatry, National Yang Ming Chiao Tung University, Taipei, Taiwan

    Shih-Jen Tsai

  • Department of Psychiatry and Human Behavior, School of Medicine, University of California, Irvine, CA, USA

    Marquis P. Vawter

  • Psychiatry, Psychiatrisches Zentrum Nordbaden, Wiesloch, Germany

    Helmut Vedder

  • Department of Child and Adolescent Psychiatry/Psychology, Erasmus MC Sophia Children Hospital, Erasmus University, Rotterdam, The Netherlands

    Annabel Vreeker

  • Department of Psychology Education and Child Studies, Erasmus School of Social and Behavioral Sciences, Erasmus University Rotterdam, Rotterdam, The Netherlands

    Annabel Vreeker

  • Department of Research, Innovation and Education, Division of Clinical Neuroscience, Oslo University Hospital, Oslo, Norway

    Bendik S. Winsvold & John-Anker Zwart

  • Department of Neurology, Oslo University Hospital, Oslo, Norway

    Bendik S. Winsvold

  • Samsung Genome Institute, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea

    Hong-Hee Won

  • Department of Psychological Medicine, Institute of Psychiatry, Psychology and Neuroscience, King’s College London, London, UK

    Allan H. Young

  • South London and Maudsley NHS Foundation Trust, Bethlem Royal Hospital, Kent, UK

    Allan H. Young

  • Department of Clinical Sciences, Psychiatry, Umeå University Medical Faculty, Umeå, Sweden

    Rolf Adolfsson

  • National Institute of Mental Health, Klecany, Czech Republic

    Martin Alda

  • Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden

    Lars Alfredsson

  • Department of Psychiatry, University of Münster, Münster, Germany

    Bernhard T. Baune

  • Department of Psychiatry, Melbourne Medical School, The University of Melbourne, Melbourne, Victoria, Australia

    Bernhard T. Baune

  • The Florey Institute of Neuroscience and Mental Health, The University of Melbourne, Parkville, Victoria, Australia

    Bernhard T. Baune & Christos Pantelis

  • Université Paris Cité, INSERM, Optimisation Thérapeutique en Neuropsychopharmacologie, UMRS-1144, Paris, France

    Frank Bellivier & Bruno Etain

  • APHP Nord, DMU Neurosciences, GHU Saint Louis-Lariboisière-Fernand Widal, Département de Psychiatrie et de Médecine Addictologique, Paris, France

    Frank Bellivier & Bruno Etain

  • Psychiatry, University of Pennsylvania, Philadelphia, PA, USA

    Wade H. Berrettini

  • Center for Statistical Genetics and Department of Biostatistics, University of Michigan, Ann Arbor, MI, USA

    Michael Boehnke & Laura J. Scott

  • University of Queensland, Brisbane, Queensland, Australia

    Stanley Catts

  • Neuropsychiatric Genetics Research Group, Department of Psychiatry and Trinity Translational Medicine Institute, Trinity College Dublin, Dublin, Ireland

    Aiden Corvin

  • National and Kapodistrian University of Athens, 1st Department of Psychiatry, Eginition Hospital, Athens, Greece

    Dimitris Dikeos

  • School of Biomedical Sciences, Faculty of Medicine and Health, University of New South Wales, Sydney, New South Wales, Australia

    Janice M. Fullerton & Peter R. Schofield

  • Department of Human Genetics, University of Chicago, Chicago, IL, USA

    Elliot S. Gershon

  • Biometric Psychiatric Genetics Research Unit, Alexandru Obregia Clinical Psychiatric Hospital, Bucharest, Romania

    Maria Grigoroiu-Serbanescu

  • Department of Psychiatric Genetics, Poznan University of Medical Sciences, Poznan, Poland

    Joanna Hauser & Joanna M. Pawlak

  • School of Medicine and Public Health, University of Newcastle, Newcastle, New South Wales, Australia

    Frans A. Henskens

  • Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden

    Jens Hjerling-Leffler

  • HUNT Research Center, Department of Public Health and Nursing, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology, Trondheim, Norway

    Kristian Hveem

  • Department of Public Health and Institute of Epidemiology and Preventive Medicine, College of Public Health, National Taiwan University, Taipei, Taiwan

    Po-Hsiu Kuo

  • Neuroscience Therapeutic Area, Janssen Research and Development, Titusville, NJ, USA

    Qingqin S. Li

  • JRD Data Science, Janssen Research and Development, Titusville, NJ, USA

    Qingqin S. Li

  • Cancer Epidemiology and Prevention, M. Sklodowska-Curie National Research Institute of Oncology, Warsaw, Poland

    Jolanta Lissowska

  • SA MRC Unit on Risk and Resilience in Mental Disorders, Department of Psychiatry, Stellenbosch University, Stellenbosch, South Africa

    Christine Lochner

  • University of Newcastle, Newcastle, New South Wales, Australia

    Carmel Loughland

  • Department of Psychiatry, Amsterdam University Medical Center, Amsterdam, The Netherlands

    Jurjen J. Luykx

  • Department of Psychiatry and Neuropsychology, School for Mental Health and Neuroscience, Maastricht University Medical Center, Maastricht, The Netherlands

    Jurjen J. Luykx

  • School of Psychology, The University of Queensland, Brisbane, Queensland, Australia

    Nicholas G. Martin & Sarah E. Medland

  • Department of Psychiatry, University of Florida, Gainesville, FL, USA

    Carol A. Mathews

  • Research Institute, Lindner Center of HOPE, Mason, OH, USA

    Susan L. McElroy

  • School of Psychology and Counselling, Queensland University of Technology, Brisbane, Queensland, Australia

    Sarah E. Medland

  • Division of Mental Health and Addiction, University of Oslo, Institute of Clinical Medicine, Oslo, Norway

    Ingrid Melle

  • Department of Mental Health, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology (NTNU), Trondheim, Norway

    Gunnar Morken

  • Psychiatry, St Olavs University Hospital, Trondheim, Norway

    Gunnar Morken

  • Psychosis Research Unit, Aarhus University Hospital-Psychiatry, Risskov, Denmark

    Ole Mors

  • NCRR and CIRRAU, Aarhus BSS, Aarhus University, Aarhus, Denmark

    Preben Bo Mortensen

  • Munich Cluster for Systems Neurology (SyNergy), Munich, Germany

    Bertram Müller-Myhsok

  • University of Liverpool, Liverpool, UK

    Bertram Müller-Myhsok

  • HudsonAlpha Institute for Biotechnology, Huntsville, AL, USA

    Richard M. Myers

  • Medical and Population Genetics, Broad Institute, Cambridge, MA, USA

    Benjamin M. Neale & Eli A. Stahl

  • Mental Health Services in the Capital Region of Denmark, Mental Health Center Copenhagen, University of Copenhagen, Copenhagen, Denmark

    Merete Nordentoft

  • Psychiatry, Indiana University School of Medicine, Indianapolis, IN, USA

    John I. Nurnberger

  • Division of Psychiatry, Haukeland Universitetssjukehus, Bergen, Norway

    Ketil J. Oedegaard

  • Faculty of Medicine and Dentistry, University of Bergen, Bergen, Norway

    Ketil J. Oedegaard

  • Center for Molecular Medicine, Stockholm, Sweden

    Tomas Olsson

  • Human Genetics and Computational Biomedicine, Pfizer Global Research and Development, Groton, CT, USA

    Sara A. Paciga

  • Melbourne Neuropsychiatry Centre, Department of Psychiatry, The University of Melbourne, Melbourne, Victoria, Australia

    Christos Pantelis

  • Monash Institute of Pharmaceutical Sciences (MIPS), Monash University, Parkville, Victoria, Australia

    Christos Pantelis

  • Rutgers Health, Rutgers University, Piscataway, NJ, USA

    Carlos N. Pato & Michele T. Pato

  • University of Patras, School of Health Sciences, Department of Pharmacy, Laboratory of Pharmacogenomics and Individualized Therapy, Patras, Greece

    George P. Patrinos

  • Department of Genetics and Genomics, College of Medicine and Health Sciences, United Arab Emirates University, Al-Ain, United Arab Emirates

    George P. Patrinos

  • Zayed Center for Health Sciences, United Arab Emirates University, Al-Ain, United Arab Emirates

    George P. Patrinos

  • Department of Pathology, Faculty of Medicine and Health Sciences, Clinical Bioinformatics Unit, Erasmus University Medical Center Rotterdam, Rotterdam, The Netherlands

    George P. Patrinos

  • Department of Neurology and Neurosurgery, Faculty of Medicine, McGill University, Montreal, Québec, Canada

    Guy A. Rouleau

  • Montreal Neurological Institute and Hospital, McGill University, Montréal, Québec, Canada

    Guy A. Rouleau

  • Center for Precision Medicine and Translational Therapeutics, James J. Peters VA Medical Center, Bronx, NY, USA

    Panos Roussos

  • Centre for Brain and Mental Health Research, The University of Newcastle, Newcastle, New South Wales, Australia

    Ulrich Schall

  • Hunter Medical Research Institute, New Lambtion Heights, New South Wales, Australia

    Ulrich Schall

  • Department of Psychiatry and Psychotherapy, University Medical Center Göttingen, Göttingen, Germany

    Thomas G. Schulze

  • Department of Psychiatry and Behavioral Sciences, SUNY Upstate Medical University, Syracuse, NY, USA

    Thomas G. Schulze

  • The School of Biomedical Sciences and Pharmacy, Faculty of Medicine, Health and Wellbeing, University of Newcastle, Newcastle, New South Wales, Australia

    Rodney J. Scott

  • Cancer Detection and Therapies Program, Hunter Medical Research Institute, University of Newcastle, Newcastle, New South Wales, Australia

    Rodney J. Scott

  • Department of Medicine and Surgery, Kore University of Enna, Enna, Italy

    Alessandro Serretti

  • Department of Biomedical and Neuromotor Sciences, University of Bologna, Bologna, Italy

    Alessandro Serretti

  • Oasi Research Institute-IRCCS, Troina, Italy

    Alessandro Serretti

  • Department of Psychiatry, Massachusetts General Hospital, Boston, MA, USA

    Jordan W. Smoller

  • Psychiatric and Neurodevelopmental Genetics Unit (PNGU), Massachusetts General Hospital, Boston, MA, USA

    Jordan W. Smoller

  • Faculty of Medicine, University of Iceland, Reykjavik, Iceland

    Kari Stefansson

  • Department of Psychiatry, Hospital Namsos, Namsos, Norway

    Eystein Stordal

  • Department of Neuroscience, Norges Teknisk Naturvitenskapelige Universitet Fakultet for naturvitenskap og teknologi, Trondheim, Norway

    Eystein Stordal

  • Hector Institute for Artificial Intelligence in Psychiatry, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany

    Fabian Streit

  • Department of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA

    Patrick F. Sullivan

  • Department of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA

    Patrick F. Sullivan & Arianna Di Florio

  • Department of Psychiatry, McGill University, Montreal, Québec, Canada

    Gustavo Turecki

  • Department of Psychiatry, Sankt Olavs Hospital Universitetssykehuset i Trondheim, Trondheim, Norway

    Arne E. Vaaler

  • Clinical Institute of Neuroscience, Hospital Clinic, University of Barcelona, IDIBAPS, CIBERSAM, Barcelona, Spain

    Eduard Vieta

  • Department of Psychology, Emory University, Atlanta, GA, USA

    Irwin D. Waldman

  • Department of Neuroscience, SUNY Upstate Medical University, Syracuse, NY, USA

    Cynthia S. Weickert & Thomas W. Weickert

  • Institute of Biological Psychiatry, Mental Health Services, Copenhagen University Hospital, Copenhagen, Denmark

    Thomas Werge

  • Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark

    Thomas Werge

  • Center for GeoGenetics, GLOBE Institute, University of Copenhagen, Copenhagen, Denmark

    Thomas Werge

  • Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis, IN, USA

    Howard J. Edenberg

  • Department of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, IN, USA

    Howard J. Edenberg

  • Centre for Human Genetics, University of Marburg, Marburg, Germany

    Andreas J. Forstner

  • Genoplan RnD Division, Genoplan Korea, Seoul, Republic of Korea

    Byung-Chul Lee, Ji-Woong Kim, Young Kee Lee, Joon Ho Kang, Myeong Jae Cheon & Dong Jun Kim

  • Genoplan RnD Division, Genoplan Japan, Fukuoka, Japan

    Byung-Chul Lee, Ji-Woong Kim, Young Kee Lee, Joon Ho Kang, Myeong Jae Cheon & Dong Jun Kim

  • Clinical Epidemiology Research Center (CERC), VA Connecticut Healthcare System, West Haven, CT, USA

    Mihaela Aslan

  • Bruce W. Carter Miami Veterans Affairs (VA) Medical Center, Miami, FL, USA

    Philip D. Harvey

  • Office of Research and Development, Veterans Health Administration, Washington, DC, USA

    Grant D. Huang

The management group for this paper was led by O.A.A. The management group comprised a subset of authors responsible for the study design, conduct, primary and final interpretation, and included A.M., A.J.F., N.M., A.D.F., R.A.O., H.J.E., K.S.O. and O.A.A; this group was also responsible for primary drafting and editing of the manuscript. The analytical team, led by K.S.O., was responsible for the main analyses presented in the paper, and included M. Koromina, T.v.d.V., T.B., F.S.D., J.M.K.Y., K.-H.L., X.W., J.R.I.C., B.L.M., C.C.M, A.V.R., P.A.L., E. Koch, A. Harder, N.P., J.B. and K.S.O. Imputation, quality control and GWAS were conducted by K.S.O., M. Koromina, B.L.M., K.-H.L., X.W. and J.M.K.Y. Heritability and genetic correlation analyses were performed by K.S.O. MiXeR was done by K.S.O. and A. Shadrin. Polygenic association was conducted by T.v.d.V., T.B., B.L.M. and P.A.L. Gene and gene set analyses were done by K.S.O., C.C.M. and A.V.R. Cell-type-specific analyses were performed by F.S.D. Single-nucleus RNA sequencing enrichment was done by A. Harder and J.H.-L. Fine-mapping was conducted by M. Koromina. Rare variant analyses were performed by C. Liao. QTL integrative analyses were done by M. Koromina, T.B. and F.S.D. Enhancer–promoter interactions were analysed by J.B. Credible gene prioritization was performed by K.S.O. and M. Koromina. Temporal clustering was done by N.P. Drug enrichment was conducted by J.R.I.C. and E. Koch. Clinical assessments were performed by A.A., A.C., A.C.-B., A.D.B., A.D.F., A.E.V., A.H.Y., A. Havdahl, A.M., A.M.M., A. Perry, A. Pfennig, A.R., A. Serretti, A.V., B. Carpiniello, B.E., B.S., B.T.B., C.A.M., C. Lavebratt, C. Loughland, C.N.P., C.O., C.S., D.D., D.H., D.J.M., D. J. Smith, D.M., D.Q., E.C.S., E.E.T., E.J.R., E. Kim, E. Sigurdsson, E.S.G., E. Stordal, E.V., E.Z.R., F. Senner, F.S.G., F. Stein, F. Streit, F.T.F., G.B., G.K., G.M., H.A., H.-J.L., H.M., H.V., H.Y.P., I.D.W., I.J., I.M., I.R.G., J.A.R.-Q., J.B.P., J.B.V., J.G.-P., J. Garnham, J. Grove, J.H., J.I.N., J. L. Kalman, J. L. Kennedy, J.L.S., J. Lawrence, J. Lissowska, J.M.P., J.P.R., J.R.D., J.W.S., K.A., K.D., K.G.-S., K.J.O., L.A.J., L.B., L.F., L. Martinsson, L. Sirignano, L.T., L.Z., M.A., M. Bauer, M. Brum, M. Budde, M.C., M.C.O., M.F., M.G., M.G.-S., M.G.M., M.H.R., M. Haraldsson, M. Hautzinger, M.I., M.J.G., M.J.O., M. Kogevinas, M. Landén, M. Lundberg, M. Manchia, M. Mattheisen, M.P.B., M.P.V., M. Rietschel, M. Tesfaye, M.T.P., M. Tesli, N.A.-R., N.B., N.B.-K., N.C., N.D., N.G.M., N.I., O.A.A., O.B.S., O.K.D., O.M., P. B. Mitchell, P. B. Mortensen, P.C., P.F., P.M.C., R.A., R.B., R.S.K., S.A.K., S. Bengeser, S.K.-S., S.L., S.L.M., S.P., T.G.S., T.H., T.H.H., T.K., T.M.K., T.O., T.S., T.W., T.W.W., U.D., U.H., V.M., W.B., W. Maier and W. Myung. Data processing and analyses were performed by A.C., A.D.B., A.F.P., A. Harder, A.J.F., A.M.D., A. Shadrin, A.V.R., A.X.M., B. Coombes, B.L.M., B.M.-M., B.M.B., B.S.W., C.B.P., C. Cruceanu, C.C.M., C. Chatzinakos, C. Liao, C.M.N., C.S.W., C. Terao, C. Toma, D.A., D.M.H., D.W.M., E.A., E.A.S., E.C.B., E.C.C., E. Koch, E.M., E.S.G., F.D., F.J.M., F.S.D., G.A.R., G.B., G.P., G.T., H.-C.C., H. Stefansson, H. Sung, H.-H.W., I.C., J.B., J.C.-D., J.D.M., J.F., J.F.F., J.G.T., J. Grove, J.H.-L., J.K., J.M.B., J.M.F., J.M.K.Y., J.R.I.C., J.S.J., J.T.R.W., K.K., K.-H.L., K.S.O., L.G.S., L.J., L. Milani, L. Sindermann, M.-C.H., M.I., M.J.C., M. Koromina, M. Leber, M.M.N., M. Mattheisen, M. Ribasés, M. Rivera, M.S.A., M.S., M. Tesfaye, N.B.F., N.I., N.M., N.P., N.W.M., O.B.S., O.F., O.K.D., P.A.H., P.A.L., P.A.T., P.D.S., P.F.S., P.H., P.-H.K., P.M., P.P.Z., P.R., Q.S.L., R.J.S., R.M.M., R.Y., S.A., S. Børte, S. Cichon, S.D., S.D.G., S.E.M., S.H., S.H.W., S.J., S.R., S.-J.T., T.A.G., T.B., T.B.B., T.C., T.D.A., T.E.T., T.F.M.A., T.O., T.S., T.v.d.V., T.W., T.W.M., V.E.-P., W. Myung, X.W. and Y.K. Funding was obtained by A.C., A.D.B., A.H.Y., A.M.M., B.E., B.M.N., B.T.B., C.N.P., C. Pantelis, C.S.W., C. Terao, D. J. Stein, D.M., D.S., E.S.G., F.B., F.J.M., G.A.R., G.B., G.P.P., G.T., H.J.E., I.B.H., I.J., I.M., I.N.F., J.A.K., J.B.P., J.B.V., J.I.N., J.M.B., J.M.F., J.R.D., J.W.S., K.H., L.A., L.A.J., L.B., M.A., M. Boehnke, M.C.O., M.F., M.G.-S., M.H.R., M.I., M.J.G., M.J.O., M. Leboyer, M. Landén, M.M.N., M.N., M. Rietschel, M.S., M.T.P., N.C., N.G.M., N.I., O.A.A., O.M., P.A.T., P. B. Mitchell, P. B. Mortensen, P.P.Z., P.R.S., R.A.O., R.J.S., R.M.M., S.E.M., S.J., S.L., T.B.B., T.G.S., T.O., T.S., T.W., T.W.W., W.H.B. and Y.K. Recruitment and genotyping were performed by A.C., A.D.B., A.D.F., A.E.V., A.H.F., A.J.F., A.M.M., A.M., A.R., A. Serretti, A. Squassina, B. Carpiniello, B.-C.L., B.E., B.M.-M., B.M.N., B.T.B., C.A.M., C.B.P., C. Lochner, C.M.N., C.M.O., C.N.P., C. Pantelis, C. Pisanu, C.S.W., D.C.W., D.D., D.J.K., E.A., E.S.G., E. Stordal, E.V., E.Z.R., F.A.H., F.B., F.J.M., F.M., F.S.G., F. Stein, G.A.R., G.B., G.D.H., G.M., G.P.P., G.T., H.J.E., H. Stefansson, H.-H.W., I.B.H., I.D.W., I.J., J.A.R.-Q., J.B.V., J.H., J.H.K., J.H.-L., J.I.N., J.J.L., J. Lissowska, J.M.B., J.M.F., J.M.P., J.R.D., J.R.K., J.-W.K., J.W.S., J.-A.Z., K.H., K.J.O., K.S., L.A., L.A.J., L.J.S., L. Milani, L.T., M.A., M. Aslan, M.C.O., M.F., M.G., M.G.-S., M.I., M.J.C., M.J.G., M.J.O., M. Leboyer, M. Landén, M.M.N., M. Manchia, M.N., M. Ribasés, M. Rietschel, M.S., M.T.P., N.C., N.G.M., N.I., O.A.A., O.M., P.A.L., P. B. Mitchell, P. B. Mortensen, P.D.H., P.F., P.-H.K., P.R., P.R.S., Q.S.L., R.A., R.A.O., R.S.K., S.A.P., S. Bengesser, S. Cichon, S. Catts, S.E.M., S.L.M., S.R., T.G.S., T.H., T.K., T.S., T.W., T.W.W., U.D., U.S., V.J.C., W.H.B., W. Myung and Y.K.L. Numerous authors beyond the initial writing group contributed to data interpretation and provided edits, comments and suggestions to the paper. All authors reviewed the manuscript critically for important intellectual content and approved the final version of the manuscript for publication. The Chair of the PGC is P.F.S. The Bipolar Disorder Working Group of the PGC is led by O.A.A.



Bipolar disorder is a complex mental health condition that affects millions of people worldwide. While the exact causes of bipolar disorder are still not fully understood, recent advancements in genomics have provided valuable insights into the biological and phenotypic aspects of this disorder.

Genomics, the study of an organism’s complete set of DNA, has allowed researchers to identify genetic variations that may play a role in the development of bipolar disorder. By analyzing the genomes of individuals with bipolar disorder, scientists have been able to pinpoint specific genes and genetic pathways that are associated with the disorder.

One of the key findings from genomic studies of bipolar disorder is the involvement of genes related to neurotransmitter signaling, synaptic function, and circadian rhythms. These genes are known to play a crucial role in regulating mood, behavior, and sleep patterns, all of which are disrupted in individuals with bipolar disorder.

In addition to identifying genetic factors, genomics has also shed light on the phenotypic aspects of bipolar disorder. By studying the patterns of gene expression and protein activity in individuals with bipolar disorder, researchers have been able to uncover the underlying biological mechanisms that contribute to the disorder’s symptoms.

Furthermore, genomics has enabled the development of personalized treatment approaches for individuals with bipolar disorder. By identifying genetic variations that may influence a person’s response to medications, doctors can tailor treatment plans to better suit each individual’s unique genetic makeup.

Overall, genomics has significantly advanced our understanding of bipolar disorder, providing valuable insights into its biological and phenotypic underpinnings. By continuing to study the genetic basis of bipolar disorder, researchers hope to uncover new therapeutic targets and improve treatment outcomes for individuals with this challenging condition.

Tags:

  1. Genomics
  2. Bipolar disorder
  3. Biological insights
  4. Phenotypic insights
  5. Mental health
  6. Genetic research
  7. Psychiatry
  8. Mood disorders
  9. Genetic factors
  10. Bipolar disorder research

#Genomics #yields #biological #phenotypic #insights #bipolar #disorder

  • The Ultimate Parenting Children with Oppositional Defiant Disorder: 13 Effective Strategies to Boost Self-Regulation in ODD Kids, Strengthen Family … Positive Reinforcement and Emotional Balance.

    The Ultimate Parenting Children with Oppositional Defiant Disorder: 13 Effective Strategies to Boost Self-Regulation in ODD Kids, Strengthen Family … Positive Reinforcement and Emotional Balance.


    Price: $12.97
    (as of Dec 28,2024 13:52:32 UTC – Details)


    From the Publisher

    Feeling overwhelmed parenting a child with odd

    Feeling overwhelmed parenting a child with odd

    how this book can help you manage odd and bring peace to your home

    how this book can help you manage odd and bring peace to your home

    what you will get from this book

    what you will get from this book

    imagine a home where things run smoothly

    imagine a home where things run smoothly

    last picture

    last picture

    ASIN ‏ : ‎ B0D6VTYG1C
    Publisher ‏ : ‎ Independently published (June 11, 2024)
    Language ‏ : ‎ English
    Paperback ‏ : ‎ 226 pages
    ISBN-13 ‏ : ‎ 979-8327300989
    Item Weight ‏ : ‎ 10.9 ounces
    Dimensions ‏ : ‎ 6 x 0.51 x 9 inches


    Parenting a child with Oppositional Defiant Disorder (ODD) can be challenging and exhausting, but with the right strategies, it is possible to help your child improve their self-regulation, strengthen family relationships, and foster emotional balance. Here are 13 effective strategies to help you navigate the ups and downs of parenting a child with ODD:

    1. Set clear and consistent boundaries: Establishing clear rules and consequences will help your child understand expectations and reduce power struggles.

    2. Use positive reinforcement: Rewarding good behavior with praise, stickers, or small rewards can motivate your child to make positive choices.

    3. Offer choices: Giving your child a sense of control by offering choices can help reduce defiance and increase cooperation.

    4. Practice empathy: Try to understand your child’s perspective and validate their feelings, even when they are challenging.

    5. Use visual aids: Visual schedules, charts, and timers can help your child understand expectations and transitions.

    6. Teach coping skills: Help your child develop healthy coping skills, such as deep breathing, mindfulness, or journaling, to manage difficult emotions.

    7. Model calm behavior: Stay calm and composed, even in the face of defiance, to model positive behavior for your child.

    8. Practice consistency: Consistency in routines, rules, and consequences can help your child feel secure and understand expectations.

    9. Seek professional help: Consider working with a therapist or counselor who specializes in ODD to develop a personalized treatment plan for your child.

    10. Focus on strengths: Encourage and praise your child for their strengths and accomplishments to boost their self-esteem and confidence.

    11. Foster positive family relationships: Spend quality time together as a family, engage in fun activities, and communicate openly to strengthen family bonds.

    12. Encourage physical activity: Regular exercise can help reduce stress and improve mood, making it easier for your child to regulate their emotions.

    13. Practice self-care: Take care of yourself by seeking support from other parents, setting boundaries, and prioritizing your own well-being to prevent burnout.

    Parenting a child with ODD is not easy, but with patience, empathy, and effective strategies, you can help your child improve their self-regulation, strengthen family relationships, and foster emotional balance. Remember to celebrate small victories and seek help when needed to support both your child and yourself on this journey.
    #Ultimate #Parenting #Children #Oppositional #Defiant #Disorder #Effective #Strategies #Boost #SelfRegulation #ODD #Kids #Strengthen #Family #Positive #Reinforcement #Emotional #Balance

    • Hello, how can I help you today?
    Gathering thoughts.. ...
    Powered by AI
    Chat Icon