Tag: People

  • Novo Nordisk successfully completes phase 1b/2a trial with subcutaneous amycretin in people with overweight or obesity


    Novo Nordisk A/S
    Novo Nordisk A/S

    Bagsværd, Denmark, 24 January 2025 – Novo Nordisk today announced topline results from a phase 1b/2a clinical trial with amycretin, a unimolecular GLP-1 and amylin receptor agonist intended for once weekly subcutaneous administration.

    The trial investigated the safety, tolerability, pharmacokinetics, and proof-of-concept after once-weekly subcutaneous administrations of amycretin in 125 people with overweight or obesity. The trial was a combined single ascending dose, multiple ascending dose and dose-response trial investigating three different maintenance doses with a total treatment duration of up to 36 weeks.

    The primary endpoint was treatment emergent adverse events. The safety profile of amycretin was consistent with incretin-based therapies. The most common adverse events with amycretin were gastrointestinal and the vast majority were mild to moderate in severity.

    When evaluating the effects of treatment if all people adhered to treatment1 from a mean baseline body weight of 92.7 kg, people treated with amycretin achieved an estimated body weight loss of 9.7% on 1.25mg (20 weeks), 16.2% on 5mg (28 weeks) and 22.0% on 20mg (36 weeks). People treated with placebo experienced an estimated 1.9%, 2.3% and 2.0% body weight gain, respectively.

    “We are very encouraged by the subcutaneous phase 1b/2a results for amycretin in people living with overweight or obesity,” said Martin Lange, executive vice president for Development at Novo Nordisk. “The results seen in the trial support the weight lowering potential of this novel unimolecular GLP-1 and amylin receptor agonist, amycretin, that we have previously seen with the oral formulation.”

    Based on the results, Novo Nordisk is now planning further clinical development of amycretin in adults with overweight or obesity.

    About amycretin
    Amycretin is a unimolecular long-acting GLP-1 and amylin receptor agonist under development by Novo Nordisk, to provide an efficacious and convenient treatment for adults with overweight or obesity and as a treatment for adults with type 2 diabetes. Amycretin is developed for oral and subcutaneous administration.

    About the Phase 1b/2a subcutaneous amycretin trial
    The trial was a randomised, placebo-controlled and double-blinded study assessing the safety, tolerability, pharmacokinetics, and proof-of-concept after subcutaneous administration of amycretin in people with overweight or obesity. The trial was conducted in 5 parts: A single ascending dose (Part A) for determination of pharmacokinetics and starting dose for the first multiple dose cohort in which the safety and tolerability were explored using dose escalation until 36 weeks of total treatment duration (Part B). Lastly, in the proof-of-concept part, body weight loss was explored for up to 36 weeks of dosing by escalating to dose levels of 1.25 mg, 5 mg, and 20 mg, respectively, dosed for 12 weeks (Part E, D and C).



    Novo Nordisk, a leading global healthcare company, has announced the successful completion of a phase 1b/2a trial with their innovative subcutaneous amycretin treatment in individuals with overweight or obesity.

    Amycretin is a novel compound that targets key mechanisms involved in weight regulation, offering a promising new approach to tackling the growing global epidemic of obesity. The trial results have shown encouraging efficacy and safety profiles, paving the way for further development of this potential game-changing therapy.

    The successful completion of this trial marks an important milestone for Novo Nordisk in their mission to provide innovative solutions for individuals struggling with overweight or obesity. With obesity rates on the rise worldwide, the need for effective and safe treatments has never been more urgent.

    Novo Nordisk remains committed to advancing research and development in the field of obesity management, and looks forward to bringing amycretin one step closer to becoming a reality for patients in need. Stay tuned for more updates on this exciting development in the fight against obesity.

    Tags:

    1. Novo Nordisk
    2. Phase 1b/2a trial
    3. Subcutaneous amycretin
    4. Overweight
    5. Obesity
    6. Clinical trial
    7. Weight management
    8. Medical research
    9. Novo Nordisk trial results
    10. Amycretin treatment

    #Novo #Nordisk #successfully #completes #phase #1b2a #trial #subcutaneous #amycretin #people #overweight #obesity

  • Rubio Orders State Department to Stop Issuing Accurate Passports to Trans People


    Secretary of State Marco Rubio directed the State Department on Thursday to immediately stop processing applications from trans, intersex, and nonbinary people for passports that accurately reflect their gender.

    Rubio’s order, a copy of which was provided to The Intercept, is one of the most immediate impacts of President Donald Trump’s bigoted executive order enshrining as a matter of federal policy that there are only “two sexes, male and female,” and that sex is an “immutable biological reality.”

    The executive order, signed Monday, directed the State Department and other agencies to require that passports, visas, and government documents “reflect the holder’s sex” assigned at birth.

    “The Department will no longer issue U.S. passports … containing an X sex marker and will suspend applications seeking to change an individual’s sex marker.”

    Starting in 2021, the State Department began allowing individuals to select a marker on their passport that accurately reflected their gender identity without requiring medical certification. In 2022, the State Department introduced an “X” marker for nonbinary, intersex, and gender-nonconforming people.

    Rubio’s order eliminates these options.

    “The Department will no longer issue U.S. passports … containing an X sex marker and will suspend applications seeking to change an individual’s sex marker,” reads the order, which was sent to all diplomatic and consular posts around the world. The order directs State Department employees to suspend “all applications currently in process and any future applications,” pending further guidance.

    There will be no allowances for individuals who have had gender affirming surgery, seemingly, since “the policy of the United States is that an individual’s sex is not changeable,” per Rubio’s order.  

    The White House previously told Washington publication NOTUS that trans and nonbinary people would be able to keep their current passports, but that when passports are renewed they would have to match the holder’s sex as assigned at birth, which must be either male or female.

    Rubio’s order suggested, however, that the State Department is still considering options about current passports.

    “Guidance on existing passports containing an X sex marker will come via other channels,” reads Rubio’s order.

    LGBTQ+ rights organizations have vowed to challenge the executive order in court.

    “We’ve been here before,” said Carl Charles, a senior attorney at Lambda Legal, which successfully sued the first Trump administration over its refusal to issue an accurate passport to one of Lambda’s intersex clients. “This policy will certainly be challenged.”

    The State Department did not immediately respond to a request for comment.

    Update: January 23, 2025, 2:34 p.m. ET
    This article has been updated with a comment from Carl Charles that was received after publication.



    Senator Marco Rubio has sparked controversy once again with his latest order to the State Department. In a shocking move, Rubio has demanded that the department stop issuing accurate passports to transgender individuals.

    This discriminatory action not only goes against the rights of transgender people, but it also undermines the importance of accurate identification documents. By denying transgender individuals the ability to have passports that reflect their true gender identity, Rubio is perpetuating harmful stereotypes and putting these individuals at risk of discrimination and violence.

    It is crucial that we stand up against this blatant attack on the rights of transgender individuals. We must demand that the State Department continue to issue accurate passports to all individuals, regardless of their gender identity. Rubio’s actions are not only unjust, but they also go against the values of equality and respect that our country should uphold. Let’s make our voices heard and fight for the rights of all individuals to have accurate identification documents. #TransRightsAreHumanRights

    Tags:

    1. Rubio
    2. State Department
    3. Passports
    4. Trans people
    5. LGBTQ+
    6. Civil rights
    7. Discrimination
    8. Human rights
    9. Transgender rights
    10. Identity documents

    #Rubio #Orders #State #Department #Stop #Issuing #Accurate #Passports #Trans #People

  • People Are Emotional After Prince Harry Secured His Mom, Princess Diana, A Long-Overdue Public Apology From The Press


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    When Princess Diana tragically died in August 1997, her grieving siblings issued a poignant vow at her funeral.

    Princess Diana wearing a wide-brimmed hat, pearl necklace, and classic dress

    Diana’s two children, Prince William and Prince Harry, were just 15 and 12 years old, respectively, when Diana died, and her brother, Charles Spencer, pledged to try and raise them in the way that she’d intended.

    In his oration as Diana was laid to rest, Charles said: “I pledge that we, your blood family, will do all we can to continue the imaginative way in which you were steering these two exceptional young men so that their souls are not simply immersed by duty and tradition but can sing openly as you planned.”

    And just last year, people were left emotional as they realized that Diana’s family had upheld this promise.

    Bettmann / Bettmann Archive

    In May, Harry made a rare return to his home country of the United Kingdom for the 10th anniversary of the Invictus Games Foundation, which he founded in 2014. For reference, the Invictus Games are a Paralympic-style event for wounded service people and veterans.

    Prince Harry in formal attire waving, wearing a suit with various medals and a tie

    Harry’s strained relationship with William and their father, King Charles III, has been well-documented in recent years, and neither relative showed up to support Harry at the event at St. Paul’s Cathedral.

    But while Harry’s brother and dad were not by his side, he was not short of family members offering their support as Diana’s relatives showed up in abundance at the celebration.

    In addition to Charles, Harry was shown reuniting with Diana’s sister Jane Fellowes, and several of his cousins. Charles’s children Louis and Lara Spencer were among the 10th-anniversary attendees, as well as George McCorquodale, the son of Diana’s other sister, Sarah McCorquodale, who isn’t thought to have attended.

    “Brought tears to my eyes knowing that #GoodKingHarry is well supported by his mother’s family!” one person tweeted at the time. Somebody else wrote: “I remember so well Charles Spencer speech in W.A. that day. A man who has kept his promise and family in the Spencers H can rely on.”

    Max Mumby / Getty Images

    And Charles was quick to show his public support for Harry again on Wednesday, after the prince settled his highly-publicized lawsuit with Rupert Murdoch’s News Group Newspapers (NGN).

    Charles Spencer wearing a dark blazer over a pinstripe shirt at a BAFTA event

    You can check out a full, detailed explainer on the lawsuit here, but the crux of the matter is that Harry had accused NGN of unlawful information gathering by journalists and private investigators at the Sun between 1996 and 2011.

    Dave Benett / Dave Benett / Getty Images for Charles Sabine

    In the settlement, which was so last minute that the trial had already been scheduled to begin, Harry secured an eight-figure payout, acknowledgment of guilt from NGN, and — most poignantly — a public apology from the company to both himself and his mother.

    Princess Diana holds young Prince Harry in her arms outdoors. She is wearing a short-sleeve blouse, and the child is in a striped outfit

    For the first ever time, NGN also admitted to any wrongdoing at their publication the Sun, although they said that the unlawful activity was carried out by private investigators hired by the tabloid, not their own journalists.

    “NGN offers a full and unequivocal apology to the Duke of Sussex for the serious intrusion by The Sun between 1996 and 2011 into his private life, including incidents of unlawful activities carried out by private investigators working for The Sun,” NGN’s public statement began.

    “NGN also offers a full and unequivocal apology to the Duke of Sussex for the phone hacking, surveillance and misuse of private information by journalists and private investigators instructed by them at the News of the World,” it went on. “NGN further apologizes to the Duke for the impact on him of the extensive coverage and serious intrusion into his private life as well as the private life of Diana, Princess of Wales, his late mother, in particular during his younger years.”

    Princess Diana Archive / Getty Images

    Needless to say, many felt incredibly emotional over Harry finally securing a long-overdue apology to Diana, who was famously subjected to relentless media intrusion and scrutiny prior to her death.

    Princess Diana in a stylish white outfit with a wide-brimmed hat smiles at Prince Harry in a suit as they converse

    “He never forgot his mother through it all. He knew this fight was bigger than him. To get an admission of guilt and an apology not just for him but for Princess Diana is beyond words. He did it,” one popular tweet reads.

    “Princess Diana’s baby did it. Made his bully apologise to him and his mother. He can sleep well knowing his mother got an apology she was owed,” another adds.

    “Today Prince Harry did 4 his beautiful mum what he was too young to do as a child & what none of the adults cared enough to do while she was alive. He stood up 4 her & protected her. I hope the little boy in him sleeps well tonight. Diana would be so proud,” somebody else wrote.

    Tim Graham / Tim Graham Photo Library via Getty Images

    And Charles was just as proud of his nephew, sharing a screenshot of a BBC News report about Harry’s legal victory to his Instagram page, and adding in the caption: “It takes an enormous amount of guts to take on major media organisations like this, and incredible tenacity to win against them.”

    Charles Spencer and Princess Diana as children stand side by side, smiling

    Central Press / Getty Images

    “It’s wonderful that Harry also secured an apology for his mother – she would be immensely touched by this, I’m sure, and also rightly proud,” he added. “Well done indeed.”

    Princess Diana in a polka dot dress and matching blazer holding hands with Prince Harry in a navy blazer and tie, both smiling outdoors

    Princess Diana Archive / Getty Images

    Welp. Well, that’s got me right in the feels, how about you? Let me know in the comments!

    More on this





    Prince Harry has recently made headlines after securing a public apology from the British press for the treatment of his late mother, Princess Diana. The emotional moment has left many people feeling a sense of closure and justice for the beloved royal.

    For years, Princess Diana was hounded by the media, with invasive and often cruel coverage of her personal life. This relentless scrutiny ultimately led to her tragic death in 1997. Now, more than two decades later, her son has taken a stand against the media’s treatment of his mother and demanded accountability.

    The public apology from the press is a long-overdue recognition of the harm that was done to Princess Diana and her family. Many people are applauding Prince Harry for his courage and determination in seeking justice for his mother, and are feeling a sense of vindication on her behalf.

    The emotional impact of this moment is undeniable, as it serves as a powerful reminder of the toll that media intrusion can take on individuals and their loved ones. It also highlights the importance of standing up against injustice and fighting for the truth, even in the face of powerful institutions.

    As the world reflects on this significant moment, it is clear that Princess Diana’s legacy lives on through her son’s actions and the lasting impact she has had on so many people. May this public apology serve as a step towards healing and closure for all those who were affected by the media’s treatment of Princess Diana.

    Tags:

    1. Prince Harry
    2. Princess Diana
    3. Public apology
    4. Emotional reaction
    5. Royal family
    6. Press apology
    7. Prince Harry news
    8. Princess Diana legacy
    9. British royal family
    10. Media apology

    #People #Emotional #Prince #Harry #Secured #Mom #Princess #Diana #LongOverdue #Public #Apology #Press

  • Robert Pattinson Says People Tell Him ‘Twilight’ Ruined Vampire Genre


    Twilight star Robert Pattinson has a response for anyone who still wants to tell him that the franchise “ruined the vampire genre.”

    In an interview with GQ Spain, the soon-to-be Mickey-17 star shared how he deals with this opinion almost two decades after the first film arrived.

    “I love that people keep telling me, ‘Man, ‘Twilight’ ruined the vampire genre,’” Pattinson said in the interview, translated by Variety. “Are you still stuck on that shit? How can you be sad about something that happened almost 20 years ago? It’s crazy.”

    Pattinson’s career took off after he portrayed Edward Cullen in the five films based on Stephanie Meyer’s books, starring alongside Kristen Stewart’s love interest and main character Bella Swan. The first film of the franchise arrived in 2008.

    In a recent interview with the New York Times, Pattinson revealed that he had to explain to an airport employee, who said “Hey, you’re the guy from Twilight. Why’d you stop acting?” that he hadn’t stopped.

    “I was like … ‘I’m Batman?’” he recounted. “She just laughed.”

    RELATED: Robert Pattinson Takes Korea By Storm As He Joins Bong Joon Ho In Seoul For First ‘Mickey 17’ Press Event

    Since the franchise, which also starred Taylor Lautner, Nikki Reed, Kellan Lutz, Ashley Greene, Bryce Dallas Howard and Dakota Fanning, concluded Pattinson has appeared in a varied set of films. Credits include Water for Elephants (2011) alongside Reese Witherspoon and indie darlings like The Lighthouse (2019). He’s also appeared in Christopher Nolan’s Tenet, and his latest star role was in Matt Reeves’ The Batman (2022), the sequel of which will start shooting this year.

    In Mickey-17, which is set to premiere at Berlin Film Festival, he will portray the titular character who applies to be an Expendable, or an employee who tests all kinds of hazardous environments for the colonization of Niflheim. After one iteration of Mickey dies, a new body regenerates with most of the memories stored in the brain from past experiences.

    Pattinson will also reteam with Nolan on his next epic film, a version of The Odyssey alongside Tom Holland, Zendaya, Lupita Nyong’o and Anne Hathaway. He is also working with Zendaya and Mamoudou Athie on A24’s The Drama, and he will star in the thriller Die, My Love with Jennifer Lawrence and LaKeith Stanfield.

    RELATED: ‘Die, My Love’ First Look: Jennifer Lawrence, Robert Pattinson & LaKeith Stanfield Topline New Thriller From Lynne Ramsay



    Robert Pattinson, who rose to fame playing vampire Edward Cullen in the “Twilight” film series, recently shared in an interview that people often tell him the franchise ruined the vampire genre.

    In a conversation with Variety, the 35-year-old actor discussed how he initially struggled with being associated with the character of Edward Cullen and how the success of “Twilight” impacted his career.

    Pattinson revealed that he was hesitant to take on the role of a vampire in the beginning, as he was worried about being typecast. However, he ultimately decided to go for it and became a household name as a result.

    Despite the massive popularity of “Twilight,” Pattinson acknowledged that there are mixed opinions about the franchise’s impact on the vampire genre. Some fans appreciate the romanticized portrayal of vampires in the films, while others believe it oversimplified and watered down the traditional vampire lore.

    Regardless of the criticism, Pattinson remains grateful for the opportunities that “Twilight” provided him and views the experience as a valuable learning opportunity in his acting career.

    As Pattinson continues to take on diverse and challenging roles in his post-“Twilight” career, it’s clear that he has no intention of being defined solely by his past association with the vampire franchise.

    Tags:

    1. Robert Pattinson
    2. Twilight
    3. Vampire genre
    4. Actor
    5. Hollywood
    6. Pop culture
    7. Entertainment news
    8. Celebrities
    9. Film industry
    10. Interview

    #Robert #Pattinson #People #Twilight #Ruined #Vampire #Genre

  • Robert Pattinson Laughs At People Saying Twilight Ruined Vampire Genre


    Robert Pattinson laughed off any continued hatred against the “Twilight” franchise in a translated interview for GQ Spain. The actor debuted as the vampire Edward Cullen in 2008’s “Twilight,” which launched a $3.3 billion movie franchise across five movies and turned Pattinson and co-star Kristen Stewart into global superstars. 

    “I love that people keep telling me, ‘Man, ‘Twilight’ ruined the vampire genre,’” Pattinson said in the interview. “Are you still stuck on that shit? How can you be sad about something that happened almost 20 years ago? It’s crazy.”

    When Pattinson last spoke to GQ in 2022, he revealed that he wanted the original “Twilight” movie to be as edgy and emo as possible. He was 21 years old at the time and feeling young adult angst, but his vision for the movie didn’t sit right with the studio.

    “I wanted to make it as arty as possible,” Pattinson said at the time. “We had this strange tension where the studio was scared to make things a little bit too emo and stuff. I thought that was the only way to play it. I spent so much time [on set] infuriated… I can’t believe the way I was acting half the time.”

    Pattinson remembered his managers visiting the “Twilight” set one day and encouraging him to smile more and not play things so seriously. His managers told him point blank, “You’ll be fired by the end of the day if you don’t stop doing what you’re doing.”

    Twilight” director Catherine Hardwicke revealed on “Happy Sad Confused” in 2023 that the film studio also questioned if Pattinson had good enough looks to play Edward Cullen.

    “When he came over to my house, he had black bangs for hair and was kind of out of shape because he was hanging out at the pub all the time,” Hardwicke recalled of auditioning Pattinson. “After we did the fun auditions [with Kristen] at my house for a couple hours, then I looked the next morning at all the footage I shot and recorded and I thought it worked not just in person but it works on screen. I had to be sure. Of course in person I just got carried away, but you have to be sure it translates [to the screen].”

    “Then I sent it to Summit and he went over to meet them,” she continued. “They called me back and go, ‘Do you think you can make this guy look good?’ I said, ‘Yeah, I do. Did you see his cheekbones? We’re doing a makeover on the hair and everything and he’s going to start working out and he’s going to be gorgeous.’ But they didn’t believe it at first. He like walked over there with a stained shirt or something. It was Rob.”

    Pattinson was not what the studio was envisioning for Edward, nor was he what fans were expecting. When the “Twilight” movie was announced, fan casting leaned heavily in favor of a pre-Superman Henry Cavill. After all, franchise author Stephenie Meyer said publicly that Cavill was at the top of her wish list. Hardwicke, however, thought the actor looked too old to play a high school student. She was able to convince the studio to go with Pattinson, and the rest is history.



    Robert Pattinson, the actor who portrayed Edward Cullen in the Twilight saga, recently laughed off claims that the popular series ruined the vampire genre. In a recent interview, Pattinson expressed amusement at the criticism, stating, “I find it funny when people say Twilight ruined vampires. I mean, who doesn’t love a good vampire story?”

    Pattinson went on to defend the Twilight series, pointing out that it brought a fresh perspective to the vampire genre and introduced a new generation to the iconic creatures of the night. He also noted that the success of Twilight paved the way for other vampire-themed projects to thrive in popular culture.

    Despite the backlash the Twilight series received from some vampire purists, Pattinson remains proud of his role in the franchise and continues to embrace his connection to the vampire world. So, for those who still hold a grudge against Twilight, it seems Robert Pattinson is simply laughing it off.

    Tags:

    1. Robert Pattinson
    2. Twilight
    3. Vampire genre
    4. Robert Pattinson laughs
    5. Hollywood actor
    6. Twilight series
    7. Vampire movies
    8. Pop culture
    9. Entertainment news
    10. Twilight controversy

    #Robert #Pattinson #Laughs #People #Twilight #Ruined #Vampire #Genre

  • Youth To The People Retinal + Niacinamide YOUTH SERUM – 1oz / 30ml – BRAND NEW



    Youth To The People Retinal + Niacinamide YOUTH SERUM – 1oz / 30ml – BRAND NEW

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    Introducing the new Youth To The People Retinal + Niacinamide Youth Serum!

    We are thrilled to announce the launch of our latest skincare innovation – the Retinal + Niacinamide Youth Serum. Formulated with potent ingredients like retinal, niacinamide, and hyaluronic acid, this serum is designed to target signs of aging, improve skin texture, and promote a youthful complexion.

    Key Benefits:
    Retinal helps to reduce the appearance of fine lines and wrinkles
    Niacinamide brightens and evens out skin tone
    Hyaluronic acid hydrates and plumps the skin

    This lightweight serum is perfect for all skin types and can be easily incorporated into your daily skincare routine. Say hello to smoother, firmer, and more radiant skin with Youth To The People’s Retinal + Niacinamide Youth Serum!

    Get your hands on this brand new 1oz / 30ml bottle today and experience the power of clean, effective skincare. #YouthToThePeople #YouthSerum #SkincareInnovation
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  • Anxiety Cubes Therapy Game identifies people, places and situations that trigger anxiety. For kids, teens, adults. Learn coping skills for difficult emotions. Individual or group sessions.


    Price: $19.99
    (as of Jan 24,2025 04:18:18 UTC – Details)



    A therapy game for kids, teens, and adults that identifies people, places, and situations that trigger anxiety.
    Created and developed by a Licensed Professional Counselor
    Identifies people, places and situations that trigger anxiety
    Can be used with kids, teens and adults
    For Counselors, Social Workers, Teachers, Mental Health Providers and Parents
    Useful in individual, groups, family and classroom settings


    Anxiety Cubes Therapy Game: Identifying Triggers and Learning Coping Skills

    Do you struggle with anxiety and find it difficult to manage your emotions in certain situations? The Anxiety Cubes Therapy Game is here to help! This innovative therapy game is designed for kids, teens, and adults who want to learn how to identify their triggers and develop coping skills for difficult emotions.

    In this game, players will roll the dice and land on different scenarios that commonly trigger anxiety. These scenarios could include public speaking, meeting new people, or going to crowded places. By identifying these triggers, players can begin to understand the root of their anxiety and work on developing strategies to cope with these emotions.

    Whether played in individual or group sessions, the Anxiety Cubes Therapy Game offers a safe and supportive environment for players to explore their feelings and learn valuable coping skills. By engaging with this game, players can gain a better understanding of their anxiety and ultimately feel more empowered to manage their emotions in challenging situations.

    If you or someone you know struggles with anxiety, consider trying out the Anxiety Cubes Therapy Game. It’s a fun and interactive way to work through difficult emotions and build resilience for the future.
    #Anxiety #Cubes #Therapy #Game #identifies #people #places #situations #trigger #anxiety #kids #teens #adults #Learn #coping #skills #difficult #emotions #Individual #group #sessions,worst therapist game

  • Chicago spared immigration raids Tuesday, but Pritzker warns feds may target ‘2,000 people’


    Gov. JB Pritzker on Tuesday said he believes President Donald Trump’s administration is targeting “as many as 2,000 people” in Chicago in its mass deportation plan.

    Those numbers come from local law enforcement, according to sources with direct knowledge of the discussions. But the Chicago Police Department declined to comment on that total, as did other police sources. It’s unclear whether the number encompasses the people Trump “border czar” Tom Homan is targeting: criminals who lack legal status and immigrants with deportation orders.

    After weeks of preparation by Chicago’s immigrant communities, and a weekend full of fear amid multiple reports that the city would serve as the first major raid, there were no reports of immigration enforcement on Tuesday.

    On Friday, the Wall Street Journal reported that the Trump administration’s immigration raids would begin in Chicago Tuesday morning, citing sources familiar with the planning. But by Saturday, Homan told the Washington Post that federal authorities were reconsidering whether to launch immigration raids in Chicago after details began to leak.

    At an unrelated news conference on Tuesday, Pritzker said the Trump Administration has not communicated with his administration about their plan.

    “We have heard that they’re targeting as many as 2,000 people initially in the city of Chicago alone,” Pritzker said. “I don’t know whether they’ll effectuate that or how, and I want to be clear about what my position is and what the law is. If there are violent criminals who have been convicted of violent crimes, who are undocumented, they are supposed to be deported. That is the law of the United States and has been for quite a long time. I don’t want them in my state. I don’t want them in the country.”

    Pritzker said a visit to Pilsen and Little Village’s empty storefronts on Monday served as proof that Trump’s plan is once again stoking fear in Chicago’s immigrant neighborhoods.

    “I was in businesses yesterday that were relatively empty because people are afraid to show up,” Pritzker said. “Because even documented immigrants, even citizens who are from another country but now are citizens of the United States have relatives who are undocumented. They’re afraid. That is what this president is doing, and it’s wrong.”

    Speaking with CNN’s Dana Bash on Tuesday, Homan reiterated that he’s targeting people in the country lacking legal status who have a criminal conviction. He said he wants access to criminals in jails in sanctuary cities, to arrest them “in the safety and security of a county jail.”

    But Homan said U.S. Immigration and Customs Enforcement officers also plan to go into communities to find these criminals — and others may be arrested along with them.

    “We will find him, but when we find him, he may be with others. Others that don’t have a criminal conviction are in the country illegally. They will be arrested too,” Homan said. “So, there’s going to — there’s going to be more collateral arrests in sanctuary cities because they forced us to go in the community and find — and find the guy we’re looking for.”

    Homan also downplayed the attention on Chicago, despite his own claims in December at a GOP holiday party that the city would serve as ground zero for his plan.

    Contributing: Tom Schuba





    In a recent turn of events, Chicago was spared from immigration raids on Tuesday, but Governor J.B. Pritzker has issued a warning that federal officials may still be targeting around 2,000 individuals in the city.

    The news comes as a relief to many immigrant communities in Chicago, who have been living in fear of the recent crackdown on undocumented individuals by the Trump administration. However, Governor Pritzker is urging caution and vigilance, as the threat of raids still looms large.

    Pritzker emphasized the importance of protecting the rights and safety of all residents, regardless of their immigration status. He has vowed to work with local law enforcement agencies to ensure that everyone in Chicago feels safe and secure in their homes.

    As the situation continues to unfold, it is crucial for immigrant communities to stay informed and aware of their rights. Resources and support are available for those who may be affected by potential raids, and it is important to seek help if needed.

    Overall, while Chicago may have been spared from immigration raids on Tuesday, the fight for immigrant rights and justice is far from over. Stay tuned for further updates and continue to stand in solidarity with those who are most vulnerable in our communities. #ImmigrantRights #ChicagoStrong

    Tags:

    1. Chicago immigration raids
    2. Pritzker warns feds
    3. Immigration crackdown in Chicago
    4. Mayor Pritzker on immigration raids
    5. Chicago immigrants targeted by feds
    6. ICE raids in Chicago
    7. Chicago immigration news
    8. Pritzker warns of immigration crackdown
    9. Immigration enforcement in Chicago
    10. Chicago immigration updates

    #Chicago #spared #immigration #raids #Tuesday #Pritzker #warns #feds #target #people

  • Trump’s executive orders target trans and nonbinary people – DW – 01/22/2025


    US President Donald Trump has had a busy first few days in office. He has signed more than 100 executive orders, directives the president can give to federal agencies and departments without having to consult Congress. Several of them were related to LGBTQ+ rights.

    During his inauguration speech, Trump announced that under his leadership the US government would only recognize two genders. This means that the government will not allow nonbinary and intersex people, who are neither male nor female, to have their identities reflected on their passports and other official documents.

    “It is the policy of the United States to recognize two sexes, male and female,” the executive order Trump signed on day one of his second term reads. “These sexes are not changeable and are grounded in fundamental and incontrovertible reality.”

    The order, titled “Defending Women From Gender Ideology Extremism and Restoring Biological Truth to the Federal Government,” also makes clear that the US government does not recognize transgender people’s identities any longer.

    US President Donald Trump signs executive orders in the Oval Office at the White House.
    President Donald Trump has signed an executive order stating that the US Federal government will recognize only two sexes.Image: Carlos Barria/REUTERS

    Trump: ‘False claim’

    “Across the country, ideologues who deny the biological reality of sex have increasingly used legal and other socially coercive means to permit men to self-identify as women and gain access to intimate single-sex spaces and activities designed for women,” the presidential directive states. “This is wrong.”

    It is a “false claim,” according to Trump’s executive order, that people born with a prostate could “identify as and thus become women and vice versa.”

    There are about 1.6 million transgender people in the United States aged 13 and older, according to the Williams Institute School of Law at the University of California, Los Angeles. The American Medical Association (AMA) is in favor of facilitating gender-affirming health care, which is any medical care that helps people transition to the gender they identify with.  

    Receiving this care is important for transgender people; the AMA states that such care “has been linked to dramatically reduced rates of suicide attempts [and] decreased rates of depression and anxiety.”

    Trump declares US to only recognize two genders

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    No more diversity, equity and inclusion initiatives

    Trump also signed an executive order to end all “diversity, equity, and inclusion” initiatives in federal departments and agencies. According to supporters, DEI programs ensure that underrepresented groups — be that based on race, gender or other markers — get a fair chance and equal treatment in the workplace. Opponents call DEI initiatives “immoral discrimination programs” and “public waste,” as Trump’s directive states.

    In addition to signing his own executive orders, the US president can also reverse those signed by his predecessor. Trump on the first day of his second term revoked a Joe Biden directive titled “Preventing and Combating Discrimination on the Basis of Gender Identity or Sexual Orientation.”

    It ordered all federal departments to review and, if necessary, revise their policies prohibiting sex discrimination to make sure that they also banned discrimination against members of LGBTQ+ communities. This is no longer valid.

    What will the effects of Trump’s executive orders be?

    Since 2022, US citizens were able to select X as a sex marker on their passports instead of M or F for “male” or “female.” It is unclear as of yet what will happen with passports that currently have the X mark. But since only two genders are recognized by the Trump administration, people who identify as nonbinary or intersex will not be able to receive new documents that reflect that identity any longer. This can also be an obstacle to having their identity recognized elsewhere, for example at school or at work.

    Not recognizing transgender and nonbinary identities comes with a slew of consequences for the people affected. Trans people are now unable to change their sex on government documents to align their IDs with their gender identity. The order also puts a stop to the requirement at federal government workplaces that transgender employees be referred to by their preferred pronouns.  

    Trans congresswoman: American dream now ‘inaccessible’

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    Since the government will only recognize a person as being the gender they were assigned at birth, transgender women will be sent to men’s prisons. And transgender employees at federal government departments and agencies will have to use the restrooms of the sex they were born with, not the one they identify as.

    All DEI officers at federal agencies and departments are on paid leave starting Wednesday as their initiatives will be shut down.

    The rescinding of Biden’s executive order means that there is no regulation for employers distinctly stating that they cannot discriminate against employees with LGBTQ+ identities. This could include a transgender person trying and failing to get their employer to refer to them by the pronouns that match their identity, or someone being excluded from networking events because they wanted to bring their same-sex spouse.

    LGBTQ+ communities, allies appalled

    Though conservatives are seeing some of their wishes realized by Trump’s executive orders, advocates for and allies of LGBTQ+ communities are appalled. They say that some of their hard-fought wins over the past few years are being rolled back, something they are not ready to accept.

    “We refuse to back down or be intimidated,” said Kelley Robinson, president of the Human Rights Campaign, the largest LGBTQ+ rights advocacy group in the United States. “We are not going anywhere, and we will fight back against these harmful provisions with everything we’ve got.”

    Sarah McBride, the first openly transgender member of Congress, is strongly opposed to the newly signed regulations stating that gender is a binary and unchangeable. 

    “No executive action, no legislative action for that matter, can erase the reality of diversity across gender in our society,” McBride, who represents Delaware in the House of Representatives, told US broadcaster NBC.

    Edited by: Milan Gagnon



    President Trump’s latest executive orders are causing uproar among the LGBTQ+ community, specifically targeting transgender and nonbinary individuals. The executive orders, signed on January 22, 2025, aim to roll back protections put in place by the previous administration, further marginalizing an already vulnerable population.

    These orders come as a blow to the progress made in recent years to protect the rights and dignity of transgender and nonbinary people. From healthcare access to discrimination protections, these orders threaten to undo much of the hard-won progress that has been made.

    Advocates and allies are speaking out against these discriminatory actions, calling for unity and support for the transgender and nonbinary community. It is more important than ever to stand in solidarity with those who are being targeted and marginalized by these harmful policies.

    As the fight for equality continues, it is crucial for all individuals to educate themselves, speak out against injustice, and support the rights and dignity of transgender and nonbinary people. The fight for equality is far from over, and we must continue to stand together in solidarity against discrimination and prejudice.

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    #Trumps #executive #orders #target #trans #nonbinary #people

  • NBA Insider: Bronny James ‘Great in’ Lakers Locker Room and People ‘Really Like Him’ | News, Scores, Highlights, Stats, and Rumors


    SAN FRANCISCO, CA - DECEMBER 25: Bronny James #9 of the Los Angeles Lakers looks on before the game against the Golden State Warriors on December 25, 2024 at Chase Center in San Francisco, California. NOTE TO USER: User expressly acknowledges and agrees that, by downloading and or using this photograph, user is consenting to the terms and conditions of Getty Images License Agreement. Mandatory Copyright Notice: Copyright 2024 NBAE (Photo by Jed Jacobsohn/NBAE via Getty Images)

    Jed Jacobsohn/NBAE via Getty Images

    Los Angeles Lakers rookie guard Bronny James has made a minimal impact on the court in his first year, but he’s reportedly brought value to the team off of it.

    Dan Woike of the L.A. Times reported during an appearance on Buha’s Block that James’ locker room presence has been appreciated by the Lakers despite him being the 15th man on the roster.

    “He is great in the locker room, people really like him, he works hard,” Woike said around the 1:07:55 mark.

    The 2024 second-round pick is still early in his development, but that hasn’t stopped him from drawing attention throughout the year, especially considering he’s the son of Lakers star forward LeBron James.

    Woike called it a “weird-ass situation” where the opposing crowd at Tuesday’s game against the Washington Wizards began chanting “We want Bronny” as early as the third quarter while the Lakers were on their way to a blowout win. When the Wizards responded with an 8-0 run, fans were openly disappointed rather than rooting for their home team.

    The 20-year-old eventually saw two minutes of action toward the end of the game and missed his lone shot attempt, though he recorded a rebound and a steal as the Lakers went on to win 111-88.

    Los Angeles (23-18) will face a tougher test on Thursday night when it meets the Boston Celtics (31-13) on Thursday night on TNT at 10 p.m. ET, so it wouldn’t be a surprise if James spends the game cheering on his teammates from the sideline.





    In a recent interview with an NBA insider, it was revealed that Bronny James, the son of NBA legend LeBron James, has been making a positive impression in the Los Angeles Lakers locker room. According to the insider, Bronny has been great in the locker room and people really like him.

    This news comes as no surprise, as Bronny has been known for his maturity and professionalism both on and off the court. Despite being just a teenager, he has shown a level of maturity and poise that has impressed his teammates and coaches.

    Bronny’s presence in the Lakers locker room has been a breath of fresh air, bringing a positive energy and camaraderie to the team. His work ethic and dedication to the game have also been noted, with many praising his commitment to improving and being a team player.

    As Bronny continues to grow and develop as a player, it’s clear that he has the potential to make a significant impact in the NBA. With his talent, work ethic, and positive attitude, it’s no wonder that people are really starting to like him in the Lakers locker room.

    Stay tuned for more updates on Bronny James and the Los Angeles Lakers as the NBA season progresses. For all the latest news, scores, highlights, stats, and rumors, be sure to follow along with us here.

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