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CBD reduces alcohol cravings in people suffering from alcoholism, clinical trial finds
Treatment effect on cue-induced activation in the left and right NAc. Credit: Molecular Psychiatry (2024). DOI: 10.1038/s41380-024-02869-y
A new study shows that cannabidiol (CBD) can reduce the craving for alcohol in people suffering from alcoholism. CBD is a natural component of the cannabis plant and has no intoxicating effects.
With their work, scientists at the Central Institute of Mental Health (CIMH) provide the first evidence that this cannabis active ingredient could help with alcohol problems. The team has published the results of their study in the journal Molecular Psychiatry.
First clinical study with CBD
Alcohol-related diseases are associated with a high level of suffering and are among the most common and devastating diseases worldwide. Despite this, only a few drugs have been approved for their treatment. Currently, the majority of patients relapse even when treated with relapse prevention medications, highlighting the need for the development of new pharmacological treatments.
Preclinical studies have shown that CBD could be promising, as it was able to significantly reduce alcohol consumption in laboratory animals. However, there has been a lack of clinical trials in humans. The ICONIC study (Investigation of the effects of Cannabidiol ON cue-InduCed alcohol craving and nucleus accumbens activation) fills this gap.
The scientists investigated how CBD influences the craving for alcohol triggered by alcohol stimuli and brain activity in the nucleus accumbens (NAc)—the NAc is a brain region associated with reward and addiction.
Tests also in a bar-like environment
The double-blind, randomized and controlled study included 28 people aged between 18 and 60 with mild to severe alcohol-related illness and was conducted at the CIMH in Mannheim.
The researchers divided the participants into two groups. One group was given a single dose of 800 mg CBD, while the other received a placebo.
The test subjects then took part in various tests in which they were exposed to alcohol stimuli or stress, for example. They were shown alcohol-related images or asked to enter an environment that resembled a bar. They assessed their craving for alcohol using questionnaires. Their brain activity was measured using a magnetic resonance tomograph.
CBD influences the reward center in the brain
The study shows that those who received CBD reported a significantly lower craving for alcohol compared to the placebo group. The authors also found that the NAc, i.e. the “reward center of the brain,” was significantly less activated in people who took CBD.
Lower activity in the NAc is associated with a lower craving for alcohol and a lower likelihood of relapse. The authors were also able to show that higher CBD levels in the blood were associated with a lower alcohol craving and less activation in the NAc.
“Our study provides initial and clear evidence that cannabidiol can help to reduce the craving for alcohol and change the brain activity associated with addiction,” says Prof. Dr. Dr. Patrick Bach, research group leader at the Addictive Behavior and Addiction Medicine at the CIMH, summarizing the results.
Scientist Sina Vetter adds, “However, further research activities are needed to answer important questions—which were not the subject of the study—such as whether the results are generally applicable and whether the effect of CBD remains stable over time.”
The research team is currently preparing a study that will also build on the findings of the ICONIC study. In the ICONICplus study, it will investigate the added value of treatment with CBD and naltrexone compared to established standard treatments for alcohol addiction.
More information:
Sina Zimmermann et al, Acute cannabidiol administration reduces alcohol craving and cue-induced nucleus accumbens activation in individuals with alcohol use disorder: the double-blind randomized controlled ICONIC trial, Molecular Psychiatry (2024). DOI: 10.1038/s41380-024-02869-yProvided by
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A recent clinical trial has found that CBD, a non-psychoactive compound found in cannabis, can significantly reduce alcohol cravings in individuals suffering from alcoholism. The study, published in the Journal of Addiction Medicine, found that participants who were given CBD showed a reduction in their desire to drink compared to those who were given a placebo.This is promising news for those struggling with alcohol addiction, as cravings are often a major obstacle to recovery. CBD has been found to have a calming effect on the brain, which may help to reduce the urge to drink. Additionally, CBD has been shown to have neuroprotective properties, which could help to repair some of the damage caused by chronic alcohol abuse.
While more research is needed to fully understand the potential benefits of CBD for alcohol addiction, this study provides hope for those looking for alternative treatments. If you or a loved one is struggling with alcoholism, consider discussing the possibility of incorporating CBD into your treatment plan with a healthcare provider.
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CBD, alcohol cravings, alcoholism, clinical trial, CBD benefits, alcohol addiction, CBD research, alcohol treatment, CBD therapy, addiction recovery
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#OLAY #Regenerist #Vitamin #Mini #Moisturizer #Trial #Size #0.5oz #SLIT,niacinamideNadine Arslanian Menendez federal trial postponed again
Former Sen. Bob Menendez’s wife’s bribery and corruption trial was postponed again and will begin in March after a physician treating her for breast cancer wrote a letter seeking another postponement to the U.S. District Court in the Southern District Court of New York.
Nadine Arslanian Menendez faces bribery and corruption charges similar to those of which her husband and three New Jersey businessmen were found guilty in July.
The former New Jersey senator, who resigned in August, was convicted after a nine-week trial in which he and the three co-defendants faced indictments in a federal corruption and bribery case brought by prosecutors in the Southern District. It was the second time in six years that Menendez faced bribery charges.
Menendez and Arslanian Menendez allegedly received cash, gold bars and a luxury car in exchange for his using his political influence.
Menendez and his co-defendants — Wael Hana, Fred Daibes and Jose Uribe — were part of a bribery scheme. They are are scheduled for sentencing on Wednesday.
When will Nadine Arslanian Menendez’s trial begin?
Arslanian Menendez’s attorney requested the Feb. 5 trial be adjourned until March 18. The prosecution took no position after reviewing the sealed document from her doctor.
“No further adjournments of the trial date will be granted absent a clear showing of medical necessity,” U.S. District Judge Sidney Stein wrote in an order.
Arslanian Menendez, who was to be tried alongside her husband last spring and summer, saw her trial postponed because of a medical condition, later revealed by her husband as breast cancer. She requested the latest delay earlier this month.
Sentencing this week:Federal judge denies former NJ Sen. Bob Menendez’s request for a new trial
In a letter to Stein, her attorney Barry Coburn asked for a further delay beyond the Feb. 5 start date, arguing that because the former senator and co-defendants Wael Hana and Fred Daibes are to be sentenced on Jan. 29, it will “substantially exacerbate the difficulty of selecting an impartial jury, to the point where doing so likely will not be possible.”
Coburn also submitted a letter at the time relating to Arslanian Menendez’s health. She was diagnosed with breast cancer last spring, and that precipitated the separation of her trial from Menendez, Hana and Daibes’ trial.
In his letter to Stein, Coburn called for her trial to be postponed for another two to three months.
Menendez, Hana and Daibes saw a second request for a new trial denied last week after the office of the U.S. attorney for the Southern District of New York discovered that it had uploaded evidence to the jury that should have been excluded. This was the second time the prosecution discovered an error with evidence on the jury’s laptop.
Uribe entered an agreement with prosecutors last year and testified at the trial of Menendez, Hana and Daibes last summer.
The highly anticipated federal trial of Nadine Arslanian Menendez has been postponed once again, causing frustration and disappointment among those closely following the case. Menendez, a former high-ranking government official, is facing a litany of charges including corruption, fraud, and conspiracy.The trial was originally set to begin last year but has been delayed multiple times due to various legal challenges and scheduling conflicts. The latest postponement is reportedly due to the defense team requesting more time to prepare their case.
Many are eagerly awaiting the start of the trial to see justice served and to uncover the truth behind the alleged criminal activities of Menendez. However, with each delay, the wait becomes longer and the anticipation grows stronger.
As the new trial date is yet to be announced, supporters and critics alike are left wondering when they will finally get the answers they seek. Stay tuned for further updates on this developing story.
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Nadine Arslanian Menendez, federal trial, trial postponement, legal proceedings, court case, legal news, criminal trial, legal system, justice system, court delays
#Nadine #Arslanian #Menendez #federal #trial #postponedHarvey Weinstein begs for rape trial to be moved up, ‘can’t hold on anymore’ amid cancer battle
Harvey Weinstein begged the court to push his trial date forward as he battles cancer.
Judge Curtis J. Farber set Weinstein’s rape retrial for April 15 during Wednesday’s hearing. However, the disgraced entertainment mogul claimed he would not be here in April.
“I’m asking and begging you to switch,” Weinstein told the judge in a rare direct address to the court. “I can’t hold on anymore. I’m holding on because I want justice for myself.”
Weinstein told Judge Farber that he was given the “wrong pills” earlier Wednesday morning but “caught” the mistake at the “right moment.”
HARVEY WEINSTEIN HOSPITALIZED AFTER ‘ALARMING BLOOD TEST’ AS REP CONFIRMS LEUKEMIA DIAGNOSIS
Harvey Weinstein begged the court for an earlier trial date due to his declining health as he battles cancer. (Jefferson Siegel/The New York Times via AP, Pool)
“I am begging for you to move your date, so we can proceed with trial as quickly as possible, so I can get out of this hellhole,” he claimed. “There are so many people suffering in Rikers island. They don’t have the same mouthpiece. It’s a medieval situation. This is something that has to be stopped.”
Farber told Weinstein and his lawyers he was trying to resolve and move the trial up, but as of now, April 15 is the date that works.
“Judge Farber demonstrated exceptional responsiveness, and we deeply appreciate his thoughtful consideration of Harvey’s condition and circumstances,” Weinstein’s representative, Juda Engelmayer, told Fox News Digital in a statement. “He is literally batting for his life. We remain confident in a swift and efficient trial process and firmly believe that Harvey will be fully exonerated.”
“I am begging for you to move your date, so we can proceed with trial as quickly as possible, so I can get out of this hellhole.”
Former film producer Harvey Weinstein has been outspoken about the conditions at Rikers Island. (Timothy A. Clary/Pool Photo via AP)
HARVEY WEINSTEIN RUSHED FROM PRISON TO HOSPITAL FOR EMERGENCY HEART SURGERY
Harvey Weinstein appears in court for a hearing in his sexual assault case on Jan. 29. (Jefferson Siegel /The New York Times via AP, Pool)
Weinstein was rushed to Bellevue Hospital in December after receiving an “alarming blood test.” At the time, his rep confirmed the former film producer had been diagnosed with leukemia.
“Mr. Weinstein, who is suffering from a number of illnesses, including leukemia, has been deprived the medical attention that someone in his medical state deserves, prisoner or not. In many ways, this mistreatment constitutes cruel and unusual punishment,” Engelmayer previously told Fox News Digital in a statement.
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Harvey Weinstein’s 2020 conviction was overturned in April 2024. (Scott Heins)
Weinstein’s team has been adamant about his declining health in recent months, claiming he is “basically getting no treatment” for his various medical issues.
“All I can tell you is he is not getting the treatment he deserves,” Weinstein’s lawyer, Arthur Aidala, said after a court hearing in July. “He needs some relief. We are very confident of the outcome of this trial… he will get acquitted. There is a lot of light at the end of the tunnel for Mr. Weinstein.”
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Harvey Weinstein was originally convicted of criminal sexual assault and third-degree rape in 2020. (Getty Images)
A New York appeals court overturned Weinstein’s 2020 rape conviction this past April, ordering a new trial in a stunning reversal of a landmark #MeToo case.
In a 4-3 decision, the court found that Weinstein’s trial judge allowed prosecutors to call women who said Weinstein had assaulted them to testify, even though their accusations did not specifically relate to the entertainment mogul’s charges.
Weinstein was sentenced to 23 years in prison after being convicted in February 2020 of forcing oral sex on TV and film production assistant Mimi Haley in 2006 and third-degree rape of hairstylist Jessica Mann in 2013. He was acquitted of first-degree rape and two counts of predatory sexual assault from actor Annabella Sciorra’s allegations of rape in the 1990s. Weinstein has denied ever engaging in non-consensual sex.
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Harvey Weinstein, the disgraced Hollywood producer currently serving a 23-year prison sentence for rape and sexual assault, has reportedly begged for his upcoming rape trial to be moved up due to his deteriorating health.Weinstein, who is battling cancer, allegedly told his lawyers that he “can’t hold on anymore” and fears that he may not live to see the trial date. The trial, originally scheduled for May 2022, is now set to take place in September of this year.
Weinstein’s legal team has argued that the delay in the trial is causing undue stress and suffering for their client, who is already in poor health. They are pushing for an expedited trial date in order to give Weinstein a chance to defend himself before it’s too late.
However, many critics have pointed out that Weinstein’s health concerns should not take precedence over the need for justice to be served. The numerous allegations of sexual misconduct and abuse against him cannot be ignored, and his health should not be used as a way to delay or manipulate the legal process.
As the trial date approaches, the public will be watching closely to see how the court handles Weinstein’s plea for an expedited trial and whether justice will be served for his victims.
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MeToo movement
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#Harvey #Weinstein #begs #rape #trial #moved #hold #anymore #cancer #battle
Cochran trial: Closing arguments heard Tuesday afternoon, jury deliberations to take place Wednesday morning
BECKLEY, W.Va. — Jury deliberations begin Wednesday morning in the murder trial of former Raleigh County pharmacist Natalie Cochran.
Natalie Cochran (WVRJA) The jury heard closing arguments from the prosecution and the defense throughout the course of the afternoon Tuesday before Judge H.L. Kirkpatrick adjourned the court until 9 a.m. Wednesday.
Cochran is accused of giving a lethal dose of insulin to her husband, Michael Cochran, 38, in 2019 once he began raising questions about the Ponzi scheme she was operating through the couple’s defense contracting business.
In her closing argument, Raleigh County assistant prosecuting attorney Ashley Acord said this was a pre-meditated murder.
“This woman, Natalie Cochran, feloniously, willfully, maliciously, deliberately, and with pre-meditation killed her husband, Michael Cochran,” Acord said.
The state rested its case last Wednesday after bringing in Forensic Pathologist Dr. Paul Uribe, who concluded, after conducting a second autopsy of Michael Cochran’s body, that he died from insulin.
On Monday, the defense rested after their expert witnesses, Forensic Pathologists Ljubisa Dragovic and Dr. Prya Banerjee, said Cochran’s death was “undetermined and undeterminable.”
Defense attorney Matthew Victor said on Tuesday that the prosecution does not have the appropriate amount of evidence to convict.
“The state cannot answer or prove beyond reasonable doubt the ‘how, how did that happen? How did this murder happen?” Victor said.
Victor, in his closing argument Tuesday, also brought up that Michael Cochran had been taking over two dozen supplements per day, as testified by the couple’s juvenile son. Victor also brought up claims that Michael Cochran was receiving supplements from out of the country, some of which were not approved by the Food and Drug Administration (FDA).
Natalie and Michael Cochran On Monday, Natalie Cochran turned her head in court as a photo of her husband’s body was shown after his remains were exhumed.
Victor says that this is not a murder, but rather a tragedy.
“Not for a moment should you think that the defense is taking his death lightly,” Victor said. “It’s a horrible tragedy, but a tragedy, not a murder.”
Meanwhile, Acord believes the evidence is there for the jury to convict. In her final remarks, she brought up the fact that Cochran did not aid her husband or take him to the hospital right after he had gone unconscious in February 2019.
Early in the trial, it was determined Cochran had a vial in her refrigerator months after her husband’s death, which was tested and determined to contain insulin.
“Natalie Cochran had the means, knowledge and opportunity to commit this crime,” Acord said.
The trial is being streamed on Court TV.
The highly anticipated closing arguments in the Cochran trial were heard on Tuesday afternoon, bringing an end to weeks of intense courtroom drama. The prosecution and defense both made their final appeals to the jury, laying out their theories of the case and urging the jurors to come to a just verdict.The prosecution argued that the evidence presented throughout the trial clearly pointed to the defendant’s guilt, painting a picture of a cold-blooded killer who meticulously planned and executed the crime. They emphasized the testimony of key witnesses and the forensic evidence that linked the defendant to the scene of the crime.
On the other hand, the defense made a passionate plea for the jury to consider the possibility of reasonable doubt. They pointed to inconsistencies in the prosecution’s case and raised questions about the reliability of certain witnesses. The defense argued that the defendant was being unfairly scapegoated and that there were other potential suspects who were not adequately investigated.
Now, as the trial enters its final phase, the jury will begin deliberations on Wednesday morning to decide the fate of the defendant. The outcome of this high-profile case hangs in the balance, with the hopes and fears of both the prosecution and defense resting on the shoulders of the twelve jurors.
Stay tuned for updates as we await the verdict in the Cochran trial.
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#Cochran #trial #Closing #arguments #heard #Tuesday #afternoon #jury #deliberations #place #Wednesday #morningVerdict reached in Natalie Cochran murder trial.
The jury has reached a verdict in the Natalie Cochran murder trial.
They will deliver their verdict shortly in Raleigh County Circuit Court.
Natalie has been charged with first-degree murder in the Feb. 2019 death of her husband, Michael.
If found guilty, she faces up to life in prison, though the jury could decide to grand her mercy, making Natalie eligible for parole after a set number of years.
If found not guilty of murder, the jury can still find Natalie guilty of involuntary manslaughter, which is a misdemeanor and carries up to a year sentence and up to a $1,000 fine.
The prosecution has alleged Natalie killed Michael by injecting him with insulin to prevent him from learning of her more than $2 million Ponzi scheme, which she admitted to running from 2017 to 2019.
Natalie is currently serving 11 years in federal prison for money laundering and wire fraud related to the Ponzi scheme.
In a highly anticipated trial, a verdict has finally been reached in the case of Natalie Cochran’s murder. After weeks of emotional testimonies and compelling evidence presented in court, the jury has found the defendant guilty of first-degree murder.Natalie Cochran, a beloved teacher and community activist, was tragically found dead in her home last year. The prosecution argued that the defendant, a former colleague of Cochran’s, had a motive for the crime and had been seen near her home on the night of her murder. DNA evidence also linked the defendant to the crime scene.
Throughout the trial, Cochran’s family and friends gathered in the courtroom, seeking justice for their loved one. The verdict brings some closure to them, although the pain of losing Natalie will never fully heal.
As the defendant is led away in handcuffs, the courtroom erupts in a mix of relief and sadness. While justice has been served, the loss of Natalie Cochran’s bright spirit will never be forgotten.
Rest in peace, Natalie Cochran. Your memory will live on in the hearts of those who loved you.
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#Verdict #reached #Natalie #Cochran #murder #trial
Blake Lively and Justin Baldoni get March 2026 trial date for her ‘It Ends With Us’ lawsuit
NEW YORK (AP) — A New York judge set a March 2026 trial date on Monday and moved an initial conference from mid-February to next week as the public feud between Blake Lively and her “It Ends With Us” costar and director Justin Baldoni continued to grow and accelerate.
And in a new and separate front in the series of legal battles surrounding the film that became a surprise hit last summer, Lively in a Texas court filed a request for a deposition of a man she says was central to turning online sentiment against her during its release and promotion.
The New York federal judge, Lewis J. Liman, told both sides in an order late Monday to prepare for a March 9, 2026, trial.
He also moved an initial conference from mid-February to next week and told lawyers to be prepared to address complaints about pretrial publicity and attorney conduct.
Liman took the actions after Lively’s lawyers claimed in a filing on Monday that an attorney for Baldoni was trying to taint potential jurors over lawsuits the actors have filed against each other.
The lawyers said Baldoni’s attorney was trying to wreck Lively’s career and turn potential New York jurors against her by creating a website to release selected documents and communications between Lively and Baldoni.
The lawyers said attorney Bryan Freedman, representing Baldoni, was “engaging in this extrajudicial campaign to influence these proceedings and the public perception of legal filings to this Court, and there already is a serious risk that his misconduct is tainting the jury pool.”
They added: “The endless stream of defamatory and extrajudicial media statements must end.”
Freedman said in a statement in response to Monday’s assertions that the “irony is not lost on anyone that Ms. Lively is so petrified of the truth that she has moved to gag it.”
“We will always respect the court; however, we will never be bullied by those suggesting we cannot defend our clients with pure, unedited facts,” the lawyer said. “All we want is for people to see the actual text messages that directly contradict her allegations, video footage that clearly shows there was no sexual harassment and all the other powerful evidence that directly contradicts any false allegations.”
In a letter to the judge on Thursday, Baldoni attorney Kevin Fritz accused Lively of a publicity campaign that left Baldoni and other defendants the “objects of public scorn and contempt.”
He said the actions had damaged those she sued so that they were “exiled from polite society and suffered damages totaling hundreds of millions of dollars due to Ms. Lively’s scorched-earth media campaign.”
In the separate filing in Hays County, Texas, a precursor to another potential lawsuit, Lively asks for an order for a deposition from Jed Wallace, a crisis management specialist she alleges was behind much of the social media manipulation surrounding the film that turned public sentiment against her through posts on Reddit and TikTok.
Wallace and his Texas-based firm Street Relations were brought on as subcontractors by publicists working with Baldoni and his production company, the filing said.
“He weaponized a digital army around the country, including in New York and Los Angeles, to create, seed, manipulate, and advance disparaging content that appeared to be authentic on social media platforms and internet chat forums,” the filing alleges.
Wallace is identified in Lively’s federal lawsuit, but he is not a defendant.
Freedman, who the filing says is Wallace’s lawyer, did not respond to a request for comment on the issue.
Lively sued Baldoni, his production company and others in New York in late December for sexual harassment and attacks on her reputation and asked for unspecified damages. Baldoni sued earlier this month, accusing Lively and her husband, “Deadpool” actor Ryan Reynolds, of defamation and extortion and seeking at least $400 million in damages.
The judge said Monday that he’ll likely combine the lawsuits for trial.
“It Ends With Us,” an adaptation of Colleen Hoover’s bestselling 2016 novel that begins as a romance but takes a dark turn into domestic violence, was released in August, exceeding box office expectations with a $50 million debut. But the movie’s release was shrouded by speculation over discord between Lively and Baldoni.
Lively came to fame through the 2005 film “The Sisterhood of the Traveling Pants,” and bolstered her stardom on the TV series “Gossip Girl” from 2007 to 2012. She has since starred in films including “The Town” and “The Shallows.”
Baldoni starred in the TV comedy “Jane the Virgin,” directed the 2019 film “Five Feet Apart” and wrote “Man Enough,” a book pushing back against traditional notions of masculinity.
___
AP Entertainment Writer Andrew Dalton reported from Los Angeles.
Actress Blake Lively and actor Justin Baldoni have been given a March 2026 trial date for the lawsuit filed against them by author Colleen Hoover over their upcoming film adaptation of her book “It Ends With Us.”Hoover alleges that Lively and Baldoni’s production company did not properly obtain the rights to adapt her book and that they have infringed on her copyright. The lawsuit has been ongoing for several years, with both parties unable to reach a settlement.
Lively and Baldoni have denied the allegations, stating that they followed all necessary legal procedures and obtained the rights to adapt the book. They are both looking forward to the trial in March 2026 to finally put the matter to rest.
Fans of the book are eagerly awaiting the outcome of the trial, hoping for a fair resolution that respects Hoover’s work while also allowing Lively and Baldoni to bring their vision of the story to the screen. Stay tuned for updates on this developing legal battle.
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Blake Lively, Justin Baldoni, March 2026 trial date, It Ends With Us lawsuit, celebrity news, legal updates, Hollywood lawsuit, entertainment industry, court proceedings, celebrity court cases
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