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Tag: Viruses
Clorox Smart Air Purifiers for Bedroom Home, True HEPA Filter, Works with Alexa, Small Rooms up to 200 Sq Ft, Removes 99.9% of Viruses, Wildfire Smoke, Mold, Allergies, Dust, AUTO Mode, Whisper Quiet
Price: $69.99
(as of Jan 27,2025 18:30:32 UTC – Details)
Control the Clorox Smart Tabletop Air Purifier with voice commands via an Alexa smart speaker or the Alexa app on your phone. It captures 99.97% of allergens and particulates* and 99.9% of viruses and bacteria** so you can breathe easier. Does not kill viruses or bacteria. Not tested with Covid-19, SARS-COVID-2. Reduction rate will potentially vary by fan speed, humidity level, room shape and size, variations in air quality, and/or placement of the unit in the room. No guarantee all the air in a room will pass through the True HEPA filter. * Before first use remove Power Adapter from inside the filter. See Use and Care guide for more information.
ALEXA VOICE INTEGRATION WITH SMART SPEAKER OR ALEXA APP. This air purifier is “Works with Alexa Certified” and easily connects to your Alexa smart speaker or the Alexa app. You can control it with your voice or through the app from anywhere: turn on or off, change settings, check filter life and more. To program unique command phrases or set a schedule, use Routines in the app.
CAPTURES 99.97% OF ALLERGENS AND PARTICULATES* AND 99.9% OF VIRUSES AND BACTERIA.** The Clorox Smart Tabletop Air Purifier has True HEPA filtration to capture 99.97%* of particles as small as 0.1 microns and a pre-filter to capture larger particles.
2 STAGE 360° FILTER: Delivers 360° air purification by capturing allergens and particulates in 2 filter layers. The outside pre-filter catches large dust particles and pet hair and the True HEPA filter captures 99.97%* of allergens and particulates and 99.9% of viruses and bacteria.**
IDEAL FOR SMALLER ROOMS. This compact air cleaner is perfect for smaller rooms like the office, dorm, bedroom, den or nursery. The 360° filter pulls in air from all directions to clean rooms up to 5 times per hour when used in a room 80 sq. ft. and 2 times an hour when used in a room up to 200 sq. ft.****
EASILY CUSTOMIZE TO ANY ROOM OR SCHEDULE: This True HEPA air purifier has 3 speeds and an app to customize air care to your needs. Use the Routines function in the app to create a schedule, such as turn air purifier on for 8 hours starting at 10 am.
WHISPER QUIET SETTING IS PERFECT AT NIGHT. Get ready for a good night’s sleep. Select the low speed for quiet air purification and turn the adjustable night-light to bright, dim or off.
GENUINE CLOROX FILTERS: Replace the filter every 6-12 months by searching for B09N54QY1R or Clorox 12020 Tabletop Replacement Filter. Maintain optimal performance with True HEPA filtration to capture 99.97%* of particles as small as 0.1 microns and a pre-filter to capture larger particles.
* 99.97% effective in capturing particles as small as 0.1 microns that enter the True HEPA filter.
** Based on independent testing results of MS2 virus and Staph aureus in a 945 cubic feet test chamber. 99.9% of MS2 virus was captured after 25 minutes and 99.9% Staph aureus was captured after 30 minutes of operation on the highest fan speed.
*** Cleaning effectiveness and filter life vary by air quality. **** Based on independent CADR testing, when operating on highest fan speed. Suggested room sizes assumes closed room with 8 ft. ceilingCustomers say
Customers find that the air purifier works well for cleaning the air and reducing dust in small spaces. They appreciate its quiet operation, compact size, and ability to fit in small corners or areas. The white noise it produces helps them sleep better and feel more comfortable. Customers also like the pleasant smell, value for money, and ease of setup.
AI-generated from the text of customer reviews
Introducing the Clorox Smart Air Purifiers for Bedroom Home! This innovative air purifier features a True HEPA filter that is proven to remove 99.9% of viruses, wildfire smoke, mold, allergies, dust, and more from the air in your home.Not only does this air purifier provide powerful purification, but it also works with Alexa for easy control and monitoring. With the ability to purify small rooms up to 200 square feet, this compact unit is perfect for bedrooms, offices, and other spaces where clean air is essential.
The Clorox Smart Air Purifier features an AUTO mode that adjusts the fan speed based on the air quality in the room, ensuring that your air is always fresh and clean. Plus, its whisper-quiet operation means you can enjoy cleaner air without any disruptive noise.
Don’t compromise on the air quality in your home. Invest in the Clorox Smart Air Purifier for Bedroom Home and breathe easy knowing that you and your family are breathing clean, purified air.
#Clorox #Smart #Air #Purifiers #Bedroom #Home #True #HEPA #Filter #Works #Alexa #Small #Rooms #Removes #Viruses #Wildfire #Smoke #Mold #Allergies #Dust #AUTO #Mode #Whisper #Quiet,cleanica 360 air purifier with wifiBLUEAIR Air Purifier for Allergy & Asthma Reduction in Small/Medium Rooms, HEPASilent Tech with WIFI features ALEXA compatible, Removes 99.97% Pet Dander Pollen Mold Dust Viruses, Classic 205, White
Price: $340.01
(as of Jan 27,2025 16:50:37 UTC – Details)
The Blueair Classic 205 is the next generation of the best-in-class Classic 203 air purifier. It is ideal for rooms up to 280 square feet such as small bedrooms and offices. Quietly capturing 99.97% of airborne particles down to 0.1 microns in size including dust, mold, pet dander and pollen, Blueair’s patented HEPASilent technology uses a unique combination of electrostatic and mechanical filtration which ensures that many of the airborne irritants that cause allergies and hay fever are captured in the most effective and efficient manner. Providing performance you can count on, all Blueair purifiers are independently tested and verified by independent testing through the Association of Home Appliance manufacturers (AHAM) for clean air delivery rate (CADR) and tested by the California EPA air resources board for no ozone emissions. It is recommended to replace the filter every 6 months, depending on use and environment.
Battle allergies, asthma and hay fever with HEPASilent technology which leverages electrostatic charge and mechanical filtration to deliver true HEPA performance capturing 99.97% of air airborne pollutants including dust, mold, pet dander, pollen.
Certified clean air delivery rate (CADR) of 180 cubic feet per minute with a superior, 4.8 air changes per hour
3 fan speeds including whisper quiet operation allow you to breathe and sleep easier without disruption. Wi-Fi connectivity-compatible with 802.11 b/g/n router on 2.4ghz Wi-Fi network band. Network security; open, WEP, WPA, & WPA2
Wi-Fi enabled for control through your Blueair friend app and amazon Alexa compatible
For small to medium rooms between 300 square feet and 400 square feet (AHAM rated at 279 square feet) such as small bedrooms, nurseries, and officesCustomers say
Customers appreciate the air purifier’s ability to filter and clean the air. They find it easy to set up and say it makes a difference in air quality. Many customers are satisfied with the quality, though some have issues with WiFi connectivity. There are differing opinions on noise level, functionality, value for money, smell, and air quality.
AI-generated from the text of customer reviews
Are you constantly battling allergies or asthma in your home? The BLUEAIR Air Purifier is here to help! Specifically designed for small to medium rooms, this air purifier utilizes HEPASilent technology to effectively remove 99.97% of pet dander, pollen, mold, dust, and even viruses from the air.But that’s not all – this air purifier also comes equipped with WIFI features, making it compatible with ALEXA for seamless control and monitoring. Say goodbye to constantly worrying about the air quality in your home – with the BLUEAIR Air Purifier, you can breathe easy knowing that your indoor air is clean and fresh.
Don’t let allergies and asthma hold you back any longer. Invest in the BLUEAIR Air Purifier Classic 205 in White today and experience the difference for yourself. Your health and well-being deserve it!
#BLUEAIR #Air #Purifier #Allergy #Asthma #Reduction #SmallMedium #Rooms #HEPASilent #Tech #WIFI #features #ALEXA #compatible #Removes #Pet #Dander #Pollen #Mold #Dust #Viruses #Classic #White,cleanica 360 air purifier with wifiIQAir Atem X – 3Pack – Smart Air Purifier for Large Room up to 4950 sq. ft., WiFi App Control, HyperHEPA Filters Viruses, Bacteria, Allergies, Asthma, Mold, Pets, Dust, Odor; Made in Germany
Price: $4,075.99
(as of Jan 27,2025 11:01:52 UTC – Details)
LARGE ROOM COVERAGE: Cleans spaces up to 4950 sq ft in 30 minutes. Highly effective against airborne allergens, viruses, bacteria, mold spores, smoke, smog, pollen, pet dander, PM2.5, ultra-fine particles and particle-bound odors. “The Best Overall” air purifier as rated by Wired Magazine.
QUIET, SPACE SAVING DESIGN: One of the quietest, high-performance air purifiers on the market. Slim, minimalist design with a depth of only 25 cm (10 inches) integrates beautifully into any space. Made at IQAir’s state-of-the-art production facility in Germany. Dimensions (including stand): H 27.1” x D 10” (H 688 x D 254 mm)
BEST-IN-CLASS PERFORMANCE: Individually tested and certified for ultra-fine particle removal. Independently tested to remove over 99.9% of viruses, bacteria and fungi. Meets US EPA standard for Energy Star certification
ADVANCED SENSOR OPERATION: Integrated air quality sensors measure PM2.5, CO2, temperature and humidity for real-time and historical display in app. Smart mode automatically adjusts fan speed based on measured air quality. Air quality is also elegantly projected behind the air purifier. Smart filters with RFID chips track captured air pollutants and monitor filter life. Typical filter life is 12-24 months.
APP CONTROL: Compatible with the world’s most popular air quality app (AirVisual). View and control of all device parameters (fan speed, smart modes, timer, filter life, real-time and historic air quality measurements). Schedule the unit to purify the air based on day, time and desired mode for maximum filter life and reduced energy cost. EPA Est. No.: 97566-DEU-1; CARB EO No.: G-22-113.Customers say
Customers find the air purifier effective in cleaning the air. They appreciate its multi-gas filter system that effectively removes dust and other contaminants. The app control works well and allows them to set up the product. Many customers are satisfied with allergen relief and ease of use. However, opinions differ on noise level, value for money, and smell.
AI-generated from the text of customer reviews
Are you looking for the ultimate air purifier for your large room? Look no further than the IQAir Atem X – 3Pack! This smart air purifier is designed to clean the air in rooms up to 4950 sq. ft., making it perfect for large living spaces, offices, or even medical facilities.With WiFi app control, you can easily monitor and adjust the air purifier from anywhere, ensuring that your air is always clean and fresh. The HyperHEPA filters are specially designed to capture even the smallest particles, including viruses, bacteria, allergens, mold, pet dander, dust, and odors.
Made in Germany, the IQAir Atem X – 3Pack is built to last and provide you with clean air for years to come. Say goodbye to allergies, asthma, and other respiratory issues with this top-of-the-line air purifier. Invest in your health and well-being today with the IQAir Atem X – 3Pack!
#IQAir #Atem #3Pack #Smart #Air #Purifier #Large #Room #WiFi #App #Control #HyperHEPA #Filters #Viruses #Bacteria #Allergies #Asthma #Mold #Pets #Dust #Odor #Germany,cleanica 360 air purifier with wifiClorox Smart Air Purifiers for Home, True HEPA Filter, Works with Alexa, Large Rooms up to 1,500 Sq Ft, Removes 99.9% of Viruses, Wildfire Smoke, Mold, Allergies, Dust, AUTO Mode, Whisper Quiet
Price: $159.99
(as of Jan 25,2025 17:30:23 UTC – Details)
The CloroxAlexa Smart Large Room Air Purifier captures 99.97% of allergens and particulates* and 99.9% of viruses and bacteria** so you can breathe easier. The 3 stage 360° filter captures particulates in 3 filter layers and includes a True HEPA filter.
ALEXA VOICE INTEGRATION WITH SMART SPEAKER OR ALEXA APP. This air purifier is “Works with Alexa Certified” and easily connects to your Alexa smart speaker or the Alexa app. You can control it with your voice or through the app from anywhere: turn on or off, change settings, check air quality and more. To program unique command phrases or set a schedule, use Routines in the app.
CAPTURES 99.97% OF ALLERGENS AND PARTICULATES AND 99.9% OF VIRUSES AND BACTERIA. With the Clorox Smart Air Purifier, you can breathe easier. It has True HEPA filtration to capture 99.97% of particles as small as 0.1 microns and 2 additional filters to capture larger particles and odors.
3 STAGE 360° FILTER: Delivers 360° air purification by capturing allergens, particulates, viruses and bacteria in 3 filter layers. The outside pre filter catches large dust particles and pet hair, then the True HEPA filter captures 99.97% of allergens and particulates and 99.9% of viruses and bacteria. The active carbon filter reduces VOCs and odors to keep air smelling fresh.
ACCURATE AIR QUALITY FEEDBACK. The air quality sensor provides real time feedback with a PM2.5 digital display, a color coded light from green/good to maroon/hazardous and by automatically adjusting the auto mode’s fan speed in response to changes in the current air quality.
AUTO MODE KEEPS YOUR AIR CLEAN AROUND THE CLOCK. Select auto mode and walk away it automatically adjusts to the ideal fan speed in response to changes in your air quality detected by the air quality sensor.
IDEAL FOR LARGE ROOMS. The 360° airflow pulls in air from all directions to clean rooms up to 5 times per hour when used in a room 320 sq. ft. and 1 time an hour when used in a room up to 1,500 sq. ft.
GENUINE CLOROX FILTERS: Replace the filter every 6 12 months by searching for B099XVM38X or Clorox 12010 Large Room Replacement Filter. Maintain optimal performance with True HEPA filtration to capture 99.97% of particles as small as 0.1 microns and 2 additional filters to capture larger particles and odors.Customers say
Customers appreciate the air purifier’s ability to clean the air effectively. They find it quiet and soothing, with a sound like a small fan. Many customers praise its functionality, ease of use, value for money, and size. However, some have differing views on the overall air quality.
AI-generated from the text of customer reviews
Introducing the Clorox Smart Air Purifier for Home – the ultimate solution for cleaner, healthier air in your living space. With a True HEPA filter and compatibility with Alexa, this air purifier is designed to remove 99.9% of viruses, wildfire smoke, mold, allergies, dust, and more from large rooms up to 1,500 sq ft.Equipped with AUTO mode and whisper-quiet operation, the Clorox Smart Air Purifier will continuously monitor and adjust to ensure optimal air quality without disrupting your daily routine. Say goodbye to stuffy, polluted air and hello to a fresh, breathable atmosphere in your home.
Don’t compromise on the air you breathe – invest in the Clorox Smart Air Purifier for a healthier, happier living environment.
#Clorox #Smart #Air #Purifiers #Home #True #HEPA #Filter #Works #Alexa #Large #Rooms #Removes #Viruses #Wildfire #Smoke #Mold #Allergies #Dust #AUTO #Mode #Whisper #Quiet,cleanica 360 air purifier with wifiWhat’s Going Around Right Now? The 4 Winter Viruses of the ‘Quad-Demic,’ Explained
Four illnesses are circulating in full force this winter, creating what many experts are calling a “quad-demic” in the U.S.
The most recent data from the Centers for Disease Control and Prevention show that “the amount of acute respiratory illness causing people to seek healthcare is at a high level.” Rates of COVID-19, seasonal influenza (the flu), and respiratory syncytial virus (RSV) are elevated across most areas of the country.
Similarly, norovirus—known commonly as the stomach flu—has been on the rise in the U.S., causing outbreaks across the country. According to CDC NoroSTAT data, a record 91 norovirus outbreaks were recorded for the week ending Dec. 5, 2024—far more outbreaks than in recent years at this time.
These simultaneously spreading viruses aren’t only a burden to public health, but put added strain on healthcare systems.
“It [has] a huge impact, not just on the individual who’s sick, but on the community,” Geeta Sood, MD, ScM, assistant professor of medicine and hospital epidemiologist at Johns Hopkins Bayview Medical Center, told Health. “The entire healthcare system can be impacted when you have high rates of all of these infections at the same time.”
Here’s what you need to know about the four viruses of the quad-demic and how to stay safe this winter.
It’s not uncommon for respiratory illnesses, like COVID, the flu, and RSV, to spread more in the winter months, and current rates of infection are pretty typical for this time of year, according to Shira Doron, MD, chief infection control officer for Tufts Medicine and hospital epidemiologist at Tufts Medical Center.
This is due to a variety of reasons, like environmental factors (cold, dry conditions can allow viruses to spread more easily), more susceptible immune systems, and frequent indoor gatherings.
Influenza in particular is ravaging most of the U.S. right now. According to the CDC’s Weekly US Influenza Surveillance Report, seasonal flu activity is elevated across most of the country, with many states seeing high or very high levels of flu.
COVID and RSV are also circulating now, but at lower levels. For the week ending Jan. 4, COVID accounted for 1.3% of emergency department visits in the U.S., while RSV made up just 0.9%. (Flu, meanwhile, accounted for 4.8% of ED visits.)
Doron told Health that she believes RSV has hit its peak for this season, while COVID rates appear to have reached a plateau. She also predicted that rates of the flu will likely start to fall in February.
Though not a respiratory illness, norovirus is also circulating in the U.S., and has caused more outbreaks than usual this season.
“Norovirus is experiencing a relatively high year,” Doron said. “It’s not a terrible outlier, but it’s not a good year for norovirus.”
The most recent data from the CDC show that, from Aug. 1 to Dec. 11, 2024, the U.S. saw 495 norovirus outbreaks—over 100 more than the same time period from 2023. In fact, the total number of outbreaks for the 2024–2025 season so far has surpassed the outbreaks reported for all previous seasons since 2012.
Even that data may be underreported, said Doron, since many people don’t seek medical care for its symptoms.
“You can’t treat norovirus, so you’re not really trying very hard to find it,” Doron said, explaining the lack of testing. “It is the most common cause of nausea, vomiting, and diarrhea, so you’re just going to generally manage it symptomatically and with hydration.”
Experts say whooping cough, walking pneumonia, and even bird flu deserve some extra attention this season.
Whooping cough (pertussis), a highly contagious bacterial infection, is returning to pre-pandemic patterns, according to the CDC. The most recent data show more than six times as many cases were reported as of Dec. 28, 2024, compared to the same time in 2023.
Earlier this season, in October, the U.S. was also seeing an increase in cases of walking pneumonia, a respiratory illness caused by the Mycoplasma pneumoniae bacteria.
Many experts are watching avian influenza–commonly known as bird flu—closely as well.
Though bird flu is still very rare, according to Doron. There have been 66 confirmed total cases of bird flu in the U.S., and one known death associated with the H5N1 virus. Most bird flu cases have been directly linked to animal exposures, such as dairy herds or poultry farms, but at least two cases have an unknown source of exposure.
And though human metapneumovirus (HMPV)—a virus that has symptoms similar to the common cold—has been in the news recently for a surge of cases in China, Doron said there’s no reason for Americans to panic.
“We can’t assume that what China sees, we will see,” said Doron. “Because they’re still in that immunity debt period of having not seen anything for so long that everyone’s getting everything at the same time.”
The precautions you take during cold and flu (and norovirus) season depend on your own risk tolerance and medical history.
Some people may feel comfortable washing their hands a little more often and keeping their distance from people who are ill. Others who may be more susceptible to infections—like immunocompromised people, the very old, or the very young—may take an extra protective step and wear a mask or limit social interactions.
It’s also wise to stay as healthy as possible (eat well, exercise often, optimize sleep) throughout the winter months, just in case.
“These respiratory infections and norovirus are inevitable. Everyone’s going to come in contact with them. You can run, but you can’t hide from them,” Doron said. “The best way to protect yourself is to be really healthy when you do get a cold.”
Winter is in full swing, and along with the chilly temperatures and snowy days come a slew of viruses that seem to be making the rounds. This year, experts are warning of a ‘Quad-Demic’ – a term used to describe the simultaneous circulation of four common viruses during the winter months. So, what exactly is going around right now? Let’s break down the four winter viruses of the ‘Quad-Demic’ and how they can affect you:1. Influenza: The flu is a common virus that typically peaks during the winter months. Symptoms include fever, cough, sore throat, body aches, and fatigue. It’s important to get vaccinated against the flu each year to protect yourself and others from getting sick.
2. Respiratory Syncytial Virus (RSV): RSV is a common virus that affects the respiratory system, particularly in young children and older adults. Symptoms include coughing, wheezing, and difficulty breathing. RSV can be serious in certain populations, so it’s important to seek medical attention if you suspect you or your child has RSV.
3. Norovirus: Norovirus is a highly contagious virus that causes stomach-related symptoms such as vomiting, diarrhea, and stomach cramps. It spreads easily in close quarters, such as schools, nursing homes, and cruise ships. Proper handwashing and hygiene practices can help prevent the spread of norovirus.
4. Rhinovirus: Rhinovirus is a common cause of the common cold, with symptoms including a runny or stuffy nose, sore throat, cough, and sneezing. While not typically serious, the common cold can be uncomfortable and disruptive. Rest, fluids, and over-the-counter medications can help alleviate symptoms.
As we navigate the ‘Quad-Demic’ this winter, it’s important to practice good hygiene, such as washing hands frequently, covering coughs and sneezes, and staying home when sick. If you experience severe symptoms or have underlying health conditions, it’s important to seek medical attention promptly. Stay safe and healthy this winter season!
Tags:
- Winter viruses
- Quad-Demic
- Common winter illnesses
- Cold and flu season
- Seasonal viruses
- Viral infections
- Respiratory illnesses
- Winter health tips
- Preventing winter viruses
- Understanding the Quad-Demic
#Whats #Winter #Viruses #QuadDemic #Explained
Respiratory viruses causing recent uptick in hospitalizations, CDC says
ROANOKE, Va. (WDBJ) – It’s that time of year when we have to be extra cautious and take care of ourselves. Respiratory viruses are spreading in our hometowns.
According to the Centers for Disease Control and Prevention, COVID-19, Influenza and RSV are the main viruses causing an increase in the number of hospitalizations.
The number of emergency department visits is continuing to grow. Most areas in Southwest Virginia are seeing an increase in all three viruses; however, more people need treatment for RSV.
RSV affects children more than anyone, but the number of adults getting it this winter is growing.
The CDC recommends washing your hands, but also teaching children the correct way to wash their hands.
It also says to cover your mouth when you sneeze and cough, clean frequently-touched surfaces and stay home or away from others when feeling sick to prevent spreading.
Copyright 2025 WDBJ. All rights reserved.
Respiratory viruses causing recent uptick in hospitalizations, CDC saysThe Centers for Disease Control and Prevention (CDC) has reported a concerning increase in hospitalizations due to respiratory viruses in recent weeks. According to the CDC, a surge in cases of respiratory syncytial virus (RSV), influenza, and other common respiratory illnesses have contributed to the spike in hospital admissions across the country.
Health officials are urging the public to take precautions to prevent the spread of these viruses, including practicing good hand hygiene, wearing masks in crowded indoor spaces, and getting vaccinated against the flu. The CDC also recommends staying home if you are feeling unwell and avoiding close contact with others who are sick.
The increase in hospitalizations is a reminder of the importance of taking steps to protect ourselves and others from respiratory illnesses, especially as we head into the fall and winter months. By following these guidelines and staying informed about the latest updates from the CDC, we can help reduce the impact of these viruses on our communities.
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respiratory viruses, hospitalizations, CDC, uptick, viral infections, respiratory illnesses, public health, outbreak, healthcare, pandemic, viral spread, prevention strategies, respiratory health, infectious diseases, CDC guidelines
#Respiratory #viruses #causing #uptick #hospitalizations #CDCGenetic Sequences of Highly Pathogenic Avian Influenza A(H5N1) Viruses Identified in a Person in Louisiana | Bird Flu
Background
This is a technical summary of an analysis of the genomic sequences of the viruses identified in two upper respiratory tract specimens from the patient who was severely ill from an infection with highly pathogenic avian influenza (HPAI) A(H5N1) virus in Louisiana. The patient was infected with A(H5N1) virus of the D1.1 genotype virus that is closely related to other D1.1 viruses recently detected in wild birds and poultry in the United States and in recent human cases in British Columbia, Canada, and Washington State. This avian influenza A(H5N1) virus genotype is different from the B3.13 genotype spreading widely and causing outbreaks in dairy cows, poultry, and other animals, with sporadic human cases in the United States. Deep sequencing of the genetic sequences from two clinical specimens from the patient in Louisiana was performed to look for changes associated with adaptation to mammals. There were some low frequency changes in the hemagglutinin (HA) gene segment of one of the specimens that are rare in people but have been reported in previous cases of A(H5N1) in other countries and most often during severe infections. One of the changes found was also identified in a specimen collected from the human case with severe illness detected in British Columbia, Canada, suggesting they emerged during the clinical course as the virus replicated in the patient. Analysis of the N1 neuraminidase (NA), matrix (M) and polymerase acid (PA) genes from the specimens showed no changes associated with known or suspected markers of reduced susceptibility to antiviral drugs.
CDC Update
December 26, 2024 – CDC has sequenced the HPAI A(H5N1) avian influenza viruses in two respiratory specimens collected from the patient in Louisiana who was severely ill from an A(H5N1) virus infection. CDC received two specimens collected at the same time from the patient while they were hospitalized for severe respiratory illness: a nasopharyngeal (NP) and combined NP/oropharyngeal (OP) swab specimens. Initial attempts to sequence the virus from the patient’s clinical respiratory specimens using standard RNA extraction and multisegment-RTPCR (M-RTPCR)1 techniques yielded only partial genomic data and virus isolation was not successful. Nucleic acid enrichment was needed to sequence complete genomes with sufficient coverage depth to meet quality thresholds. CDC compared the influenza gene segments from each specimen with A(H5N1) virus sequences from dairy cows, wild birds, poultry and other human cases in the U.S. and Canada. The genomes of the virus (A/Louisiana/12/2024) from each clinical specimen are publicly posted in GISAID (EPI_ISL_19634827 and EPI_ISL_19634828) and GenBank (PQ809549-PQ809564).
Summary of amino acid mixtures identified in the hemagglutinin (HA) of clinical specimens from the patient.
Overall, the hemagglutinin (HA) sequences from the two clinical specimens were closely related to HA sequences detected in other D1.1 genotype viruses, including viruses sequenced from samples collected in November and December 2024 in wild birds and poultry in Louisiana. The HA genes of these viruses also were closely related to the A/Ezo red fox/Hokkaido/1/2022 candidate vaccine virus (CVV) with 2 or 3 amino acid changes detected. These viruses have, on average, 3 or 4 amino acid changes in the HA when compared directly to the A/Astrakhan/3212/2020 CVV sequence. These data indicate the viruses detected in respiratory specimens from this patient are closely related to existing HPAI A(H5N1) CVVs that are already available to manufacturers, and which could be used to make vaccines if needed.
There were some differences detected between the NP/OP and the NP specimens. Despite the very close similarity of the D1.1 sequences from the Louisiana human case to bird viruses, deep sequence analysis of the HA gene segment from the combined NP/OP sample detected low frequency mixed nucleotides corresponding to notable amino acid residues (using mature HA sequence numbering):
- A134A/V [Alanine 88%, Valine 12%];
- N182N/K [Asparagine 65%, Lysine 35%]; and
- E186E/D [Glutamic acid 92%, Aspartic Acid 8%].
The NP specimen, notably, did not have these low frequency changes indicating they may have been detected from swabbing the oropharyngeal cavity of the patient. While these low frequency changes are rare in humans, they have been reported in previous cases of A(H5N1) in other countries and most often during severe disease2345. The E186E/D mixture, for example, was also identified in a specimen collected from the severe human case detected in British Columbia, Canada67.
This summary analysis focuses on mixed nucleotide detections at residues A134V, N182K, E186D as these changes may result in increased virus binding to α2-6 cell receptors found in the upper respiratory tract of humans. It is important to note that these changes represent a small proportion of the total virus population identified in the sample analyzed (i.e., the virus still maintains a majority of ‘avian’ amino acids at the residues associated with receptor binding). The changes observed were likely generated by replication of this virus in the patient with advanced disease rather than primarily transmitted at the time of infection. Comparison of influenza A(H5) sequence data from viruses identified in wild birds and poultry in Louisiana, including poultry identified on the property of the patient, and other regions of the United States did not identify these changes. Of note, virus sequences from poultry sampled on the patient’s property were nearly identical to the virus sequences from the patient but did not have the mixed nucleotides identified in the patient’s clinical sample, strongly suggesting that the changes emerged during infection as virus replicated in the patient. Although concerning, and a reminder that A(H5N1) viruses can develop changes during the clinical course of a human infection, these changes would be more concerning if found in animal hosts or in early stages of infection (e.g., within a few days of symptom onset) when these changes might be more likely to facilitate spread to close contacts. Notably, in this case, no transmission from the patient in Louisiana to other persons has been identified. The Louisiana Department of Public Health and CDC are collaborating to generate additional sequence data from sequential patient specimens to facilitate further genetic and virologic analysis.
Additional genomic analysis
The genetic sequences of the A(H5N1) viruses from the patient in Louisiana did not have the PB2 E627K change or other changes in polymerase genes associated with adaptation to mammals and no evidence of low frequency changes at critical positions. And, like other D1.1 genotype viruses found in birds, the sequences lack PB2 M631L, which is associated with viral adaptation to mammalian hosts, and which has been detected in >99% of dairy cow sequences but is only sporadically found in birds. Analysis of the N1 neuraminidase (NA), matrix (M) and polymerase acid (PA) genes from the specimens showed no changes associated with known or suspected markers of reduced susceptibility to antiviral drugs. The remainder of the genetic sequences of A/Louisiana/12/2024 were closely related to sequences detected in wild bird and poultry D1.1 genotype viruses, including poultry identified on the property of the patient, providing further evidence that the human case was most likely infected following exposure to birds infected with D1.1 genotype virus.
Follow Up Actions
Overall, CDC considers the risk to the general public associated with the ongoing U.S. HPAI A(H5N1) outbreak has not changed and remains low. The detection of a severe human case with genetic changes in a clinical specimen underscores the importance of ongoing genomic surveillance in people and animals, containment of avian influenza A(H5) outbreaks in dairy cattle and poultry, and prevention measures among people with exposure to infected animals or environments.
Recently, genetic sequences of highly pathogenic Avian Influenza A(H5N1) viruses have been identified in a person in Louisiana. This discovery has raised concerns about the potential for bird flu to spread to humans.The H5N1 virus is known to primarily infect birds, particularly poultry. However, there have been cases of transmission to humans in the past, leading to severe illness and even death. The genetic sequencing of the virus found in the individual in Louisiana suggests that this strain may have the potential to spread to humans more easily.
Health officials are closely monitoring the situation and taking steps to prevent further spread of the virus. It is important for people to take precautions, such as avoiding contact with sick birds and practicing good hygiene, to reduce the risk of contracting the virus.
This discovery highlights the ongoing threat of avian influenza and the importance of continued surveillance and research to better understand and control the spread of these viruses. Stay informed and stay safe. #BirdFlu #H5N1 #AvianInfluenza #Louisiana #GeneticSequences
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Remove Viruses + Speed Up PC USB Computer Repair Recovery 4 Windows+Bonus tools_
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Price: $68.39
(as of Dec 24,2024 20:39:48 UTC – Details)
ASIN : B0CW1GBG2T
Publisher : CRC Press; 2nd edition (March 25, 2024)
Publication date : March 25, 2024
Language : English
File size : 83496 KB
Simultaneous device usage : Up to 4 simultaneous devices, per publisher limits
Text-to-Speech : Not enabled
Enhanced typesetting : Not Enabled
X-Ray : Not Enabled
Word Wise : Not Enabled
Format : Print Replica
Molecular and Cellular Biology of VirusesViruses are microscopic infectious agents that can infect all forms of life, from bacteria to humans. Understanding the molecular and cellular biology of viruses is crucial for developing treatments and vaccines to combat viral infections.
Viruses are composed of genetic material, either DNA or RNA, surrounded by a protein coat called a capsid. Some viruses also have an outer envelope made of lipids stolen from the host cell. Viruses cannot reproduce on their own and must infect host cells to replicate.
The process of viral infection begins with attachment of the virus to specific receptors on the surface of the host cell. The virus then enters the cell, either by direct fusion with the cell membrane or by endocytosis. Once inside the cell, the virus releases its genetic material and hijacks the host cell’s machinery to replicate itself.
The replication of viruses can vary depending on the type of virus. DNA viruses replicate in the nucleus of the host cell, while RNA viruses replicate in the cytoplasm. Some viruses, like retroviruses, use an enzyme called reverse transcriptase to convert their RNA genome into DNA before integrating it into the host cell’s genome.
The immune system plays a crucial role in fighting viral infections. Immune cells recognize viral proteins as foreign and mount an immune response to eliminate the virus-infected cells. Vaccines work by stimulating the immune system to produce antibodies against specific viral proteins, providing immunity against future infections.
Overall, understanding the molecular and cellular biology of viruses is essential for developing effective strategies to prevent and treat viral infections. Ongoing research in this field continues to uncover new insights into the complex interactions between viruses and their host cells, leading to the development of novel antiviral therapies.
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